PDF(Pubmed)
Abstract：
UNASSIGNED: The classic ketogenic diet (cKD) is an isocaloric, high fat, low-carbohydrate diet that induces the production of ketone bodies. High consumption of dietary fatty acids, particularly long-chain saturated fatty acids, could impair nutritional status and increase cardiovascular risk. The purpose of this study was to evaluate the long-term effects of a 5-year cKD on body composition, resting energy expenditure, and biochemical parameters in children affected by Glucose Transporter 1 Deficiency Syndrome (GLUT1DS).
UNASSIGNED: This was a prospective, multicenter, 5-year longitudinal study of children with GLUT1DS treated with a cKD. The primary outcome was to assess the change in nutritional status compared with pre-intervention, considering anthropometric measurements, body composition, resting energy expenditure, and biochemical parameters such as glucose and lipid profiles, liver enzymes, uric acid, creatinine, and ketonemia. Assessments were conducted at pre-intervention and every 12 months of cKD interventions.
UNASSIGNED: Ketone bodies increased significantly in children and adolescents, and remained stable at 5 years, depending on the diet. No significant differences were reported in anthropometric and body composition standards, as well as in resting energy expenditure and biochemical parameters. Bone mineral density increased significantly over time according to increasing age. Body fat percentage significantly and gradually decreased in line with the increase in body weight and the consequent growth in lean mass. As expected, we observed a negative trend in respiratory quotient, while fasting insulin and insulin resistance were found to decrease significantly after cKD initiation.
UNASSIGNED: Long-term adherence to cKD showed a good safety profile on anthropometric measurements, body composition, resting energy expenditure, and biochemical parameters, and we found no evidence of potential adverse effects on the nutritional status of children and adolescents.
UNASSIGNED: This was a prospective, multicenter, 5-year longitudinal study of children with GLUT1DS treated with a cKD. The primary outcome was to assess the change in nutritional status compared with pre-intervention, considering anthropometric measurements, body composition, resting energy expenditure, and biochemical parameters such as glucose and lipid profiles, liver enzymes, uric acid, creatinine, and ketonemia. Assessments were conducted at pre-intervention and every 12 months of cKD interventions.
UNASSIGNED: Ketone bodies increased significantly in children and adolescents, and remained stable at 5 years, depending on the diet. No significant differences were reported in anthropometric and body composition standards, as well as in resting energy expenditure and biochemical parameters. Bone mineral density increased significantly over time according to increasing age. Body fat percentage significantly and gradually decreased in line with the increase in body weight and the consequent growth in lean mass. As expected, we observed a negative trend in respiratory quotient, while fasting insulin and insulin resistance were found to decrease significantly after cKD initiation.
UNASSIGNED: Long-term adherence to cKD showed a good safety profile on anthropometric measurements, body composition, resting energy expenditure, and biochemical parameters, and we found no evidence of potential adverse effects on the nutritional status of children and adolescents.
摘要：
■经典的生酮饮食（cKD）是等热量的，高脂肪,诱导酮体产生的低碳水化合物饮食。膳食脂肪酸的高消费，特别是长链饱和脂肪酸，可能会损害营养状况并增加心血管风险。这项研究的目的是评估5年cKD对身体成分的长期影响，静息能量消耗，受葡萄糖转运蛋白1缺乏症（GLUT1DS）影响的儿童的生化指标。
■这是一个前景，多中心，用cKD治疗的GLUT1DS儿童的5年纵向研究。主要结果是评估营养状况与干预前相比的变化，考虑到人体测量，身体成分,静息能量消耗，和生化参数，如葡萄糖和脂质分布，肝酶，尿酸,肌酐,还有酮症.在干预前和每12个月cKD干预时进行评估。
■儿童和青少年的酮体显著增加，并在5年内保持稳定，取决于饮食。人体测量和身体成分标准没有显着差异，以及静息能量消耗和生化参数。随着年龄的增长，骨密度随着时间的推移显着增加。随着体重的增加和瘦体重的增加，体脂百分比显着逐渐降低。不出所料,我们观察到呼吸商呈负趋势，而空腹胰岛素和胰岛素抵抗在cKD开始后显著降低。
■长期坚持使用cKD在人体测量中显示出良好的安全性，身体成分,静息能量消耗，和生化参数，我们没有发现对儿童和青少年营养状况潜在不利影响的证据.
■这是一个前景，多中心，用cKD治疗的GLUT1DS儿童的5年纵向研究。主要结果是评估营养状况与干预前相比的变化，考虑到人体测量，身体成分,静息能量消耗，和生化参数，如葡萄糖和脂质分布，肝酶，尿酸,肌酐,还有酮症.在干预前和每12个月cKD干预时进行评估。
■儿童和青少年的酮体显著增加，并在5年内保持稳定，取决于饮食。人体测量和身体成分标准没有显着差异，以及静息能量消耗和生化参数。随着年龄的增长，骨密度随着时间的推移显着增加。随着体重的增加和瘦体重的增加，体脂百分比显着逐渐降低。不出所料,我们观察到呼吸商呈负趋势，而空腹胰岛素和胰岛素抵抗在cKD开始后显著降低。
■长期坚持使用cKD在人体测量中显示出良好的安全性，身体成分,静息能量消耗，和生化参数，我们没有发现对儿童和青少年营养状况潜在不利影响的证据.
