Abstract：
BACKGROUND: The venom of Crotalus durissus terrificus, as well as its fractions, has intrigued research groups worldwide who are working to isolate, characterize, and find possible biotechnological applications. A number of studies have elucidated that these fractions and their derivatives possess pharmacological properties, which can enable the development of new drug prototypes with anti-inflammatory, antinociceptive, antitumor, antiviral, and antiparasitic applications.
OBJECTIVE: This review presents a systematic study on Crotalus durissus terrificus, the most notable crotalid subspecies in South America, focusing on the composition, toxicological mechanisms, structural aspects, and applications of the main venom toxins (convulxin, gyroxin, crotamine, crotoxin, and their subunits).
CONCLUSIONS: The authors have found that research on this snake and its toxins is still an area of focus, despite that almost a century has passed since the isolation of crotoxin. Several applications of these proteins in the development of novel drugs and bioactive substances have also been demonstrated.
OBJECTIVE: This review presents a systematic study on Crotalus durissus terrificus, the most notable crotalid subspecies in South America, focusing on the composition, toxicological mechanisms, structural aspects, and applications of the main venom toxins (convulxin, gyroxin, crotamine, crotoxin, and their subunits).
CONCLUSIONS: The authors have found that research on this snake and its toxins is still an area of focus, despite that almost a century has passed since the isolation of crotoxin. Several applications of these proteins in the development of novel drugs and bioactive substances have also been demonstrated.
摘要：
背景：Crotalusduriscus的毒液，以及它的分数，吸引了全世界正在努力隔离的研究小组，表征，并找到可能的生物技术应用。许多研究已经阐明，这些馏分及其衍生物具有药理学性质，可以开发具有抗炎作用的新药原型，抗伤害性,抗肿瘤，抗病毒，和抗寄生虫的应用。
目的：这篇综述提出了一项关于短尾蛇的系统研究，南美最著名的crotalid亚种，专注于构图，毒理学机制，结构方面，和主要毒液毒素(惊厥素，陀螺新,巴豆胺,crotoxin,及其子单位)。
结论：作者发现，对这种蛇及其毒素的研究仍然是一个重点领域，尽管自从分离crotoxin以来已经过去了近一个世纪。这些蛋白质在新药和生物活性物质的开发中的一些应用也已被证明。
目的：这篇综述提出了一项关于短尾蛇的系统研究，南美最著名的crotalid亚种，专注于构图，毒理学机制，结构方面，和主要毒液毒素(惊厥素，陀螺新,巴豆胺,crotoxin,及其子单位)。
结论：作者发现，对这种蛇及其毒素的研究仍然是一个重点领域，尽管自从分离crotoxin以来已经过去了近一个世纪。这些蛋白质在新药和生物活性物质的开发中的一些应用也已被证明。
