PDF(Pubmed)
Abstract：
Polymyxin B and colistin are considered the last therapeutic option to treat infections caused by highly drug-resistant bacteria. However, their administration may lead to various adverse effects such as nephrotoxicity, neurotoxicity, and allergic reactions. The current case report presents the clinical manifestation of polymyxin B-associated neurotoxicity in a female patient with no chronic illness history. The patient was rescued from under rubble during an earthquake. She was diagnosed with an intra-abdominal infection caused by Acinetobacter baumannii (A. baumannii) After the initiation of the polymyxin B infusion, the patient developed numbness and tingling sensations in her hands, face, and head. On discontinuing polymyxin B and starting colistimethate, the patient\'s symptoms improved. Therefore, healthcare professionals should be aware of the potential risk factors associated with neurotoxicity in patients receiving polymyxin B. On identifying such symptoms treatment should be discontinued promptly to prevent further neurological damage.
摘要：
多粘菌素B和粘菌素被认为是治疗由高度耐药细菌引起的感染的最后一种治疗选择。然而,它们的给药可能导致各种不良反应，如肾毒性，神经毒性，和过敏反应。目前的病例报告显示了一名无慢性病史的女性患者多粘菌素B相关神经毒性的临床表现。病人在地震中被从瓦砾中救出。她被诊断为鲍曼不动杆菌引起的腹腔内感染（A.鲍曼不动)多粘菌素B输注开始后，病人出现了双手麻木和刺痛感，脸,和头。停止多粘菌素B并开始使用多粘菌素甲磺酸盐后，患者的症状有所改善。因此,在接受多粘菌素B治疗的患者中,医护人员应了解与神经毒性相关的潜在危险因素。在发现此类症状后,应及时停止治疗,以防止进一步的神经损伤.
