Abstract：
UNASSIGNED: Transcervical resection of adhesion (TCRA) and postoperative adjuvant estrogen and progestin are the main treatments for cavity adhesions, but the recurrence rate after surgery is still high. It was showed that aspirin could promote endometrial proliferation and repair after TCRA in patients with severe cavity adhesions, but the effect on reproduction was uncertain.
UNASSIGNED: To assess the effect of aspirin on uterine arterial blood flow and endometrium in moderate and severe intrauterine adhesion after transcervical resection of adhesion.
UNASSIGNED: The databases used included Cumulative Index to PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang database. Studies published before June 2022 were included. Each participant received an aspirin-based intervention aimed at improving uterine status, which was compared to a sham intervention. The primary outcome measure was a change in endometrium thickness. Secondary outcomes included uterine artery resistance index, blood flow index, and endometrial arterial resistance index.
UNASSIGNED: A total of 19 studies (n = 1361 participants) that met the inclusion criteria were included in this study. The aspirin-based intervention was strongly associated with better clinical outcome at second-look endometrium thickness (MD 0.81, CI 0.46-1.16; p < .00001) and blood flow Index (FI) (MD 4.1, CI 2.3-5.9; p < .00001). Besides, the analysis of arterial pulsatility index (PI) showed a significantly reduced after transcervical resection of adhesion (MD -0.9, CI -1.2 to 0.6; p < .00001); whereas no significant difference was found in endometrial arterial resistance index (RI) (95% CI, -0.30 to 0.01; p = .07).
UNASSIGNED: Our study proved the effect of aspirin on uterine arterial blood flow and endometrium in moderate and severe intrauterine adhesion after transcervical resection of adhesion. However, the review requires evidence from additional randomized controlled trials and high-quality research. More strictly designed research studies are needed to assess the effectiveness of aspirin administration after transcervical resection of adhesion.
UNASSIGNED: To assess the effect of aspirin on uterine arterial blood flow and endometrium in moderate and severe intrauterine adhesion after transcervical resection of adhesion.
UNASSIGNED: The databases used included Cumulative Index to PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang database. Studies published before June 2022 were included. Each participant received an aspirin-based intervention aimed at improving uterine status, which was compared to a sham intervention. The primary outcome measure was a change in endometrium thickness. Secondary outcomes included uterine artery resistance index, blood flow index, and endometrial arterial resistance index.
UNASSIGNED: A total of 19 studies (n = 1361 participants) that met the inclusion criteria were included in this study. The aspirin-based intervention was strongly associated with better clinical outcome at second-look endometrium thickness (MD 0.81, CI 0.46-1.16; p < .00001) and blood flow Index (FI) (MD 4.1, CI 2.3-5.9; p < .00001). Besides, the analysis of arterial pulsatility index (PI) showed a significantly reduced after transcervical resection of adhesion (MD -0.9, CI -1.2 to 0.6; p < .00001); whereas no significant difference was found in endometrial arterial resistance index (RI) (95% CI, -0.30 to 0.01; p = .07).
UNASSIGNED: Our study proved the effect of aspirin on uterine arterial blood flow and endometrium in moderate and severe intrauterine adhesion after transcervical resection of adhesion. However, the review requires evidence from additional randomized controlled trials and high-quality research. More strictly designed research studies are needed to assess the effectiveness of aspirin administration after transcervical resection of adhesion.
摘要：
■经宫颈粘连切除术（TCRA）和术后辅助雌激素和孕激素是腔粘连的主要治疗方法，但术后复发率仍然很高。提示阿司匹林可促进严重腔粘连患者TCRA术后子宫内膜增殖和修复,但是对生殖的影响是不确定的。
■评估阿司匹林对中重度宫腔粘连经宫颈粘连切除术后子宫动脉血流和子宫内膜的影响。
■使用的数据库包括PubMed的累积索引，EMBASE,中国国家知识基础设施(CNKI),和万方数据库。包括2022年6月之前发表的研究。每位参与者都接受了以阿司匹林为基础的干预措施，旨在改善子宫状态，这被比作假干预。主要结局指标是子宫内膜厚度的变化。次要结果包括子宫动脉阻力指数,血流指数,子宫内膜动脉阻力指数。
■本研究共纳入19项符合纳入标准的研究（n=1361名参与者）。基于阿司匹林的干预措施与第二眼子宫内膜厚度（MD0.81，CI0.46-1.16；p<.00001）和血流指数（FI）（MD4.1，CI2.3-5.9；p<.00001）的更好临床结局密切相关。此外,动脉搏动指数（PI）的分析显示，经宫颈粘连切除术后明显减少（MD-0.9，CI-1.2至0.6；p<.00001）；而子宫内膜动脉阻力指数（RI）没有显着差异（95％CI，-0.30至0.01；p=.07）。
■我们的研究证明了阿司匹林在经宫颈切除粘连后的中度和重度宫腔粘连中对子宫动脉血流和子宫内膜的影响。然而,本综述需要来自其他随机对照试验和高质量研究的证据.需要更严格设计的研究来评估经宫颈粘连切除术后阿司匹林给药的有效性。
■评估阿司匹林对中重度宫腔粘连经宫颈粘连切除术后子宫动脉血流和子宫内膜的影响。
■使用的数据库包括PubMed的累积索引，EMBASE,中国国家知识基础设施(CNKI),和万方数据库。包括2022年6月之前发表的研究。每位参与者都接受了以阿司匹林为基础的干预措施，旨在改善子宫状态，这被比作假干预。主要结局指标是子宫内膜厚度的变化。次要结果包括子宫动脉阻力指数,血流指数,子宫内膜动脉阻力指数。
■本研究共纳入19项符合纳入标准的研究（n=1361名参与者）。基于阿司匹林的干预措施与第二眼子宫内膜厚度（MD0.81，CI0.46-1.16；p<.00001）和血流指数（FI）（MD4.1，CI2.3-5.9；p<.00001）的更好临床结局密切相关。此外,动脉搏动指数（PI）的分析显示，经宫颈粘连切除术后明显减少（MD-0.9，CI-1.2至0.6；p<.00001）；而子宫内膜动脉阻力指数（RI）没有显着差异（95％CI，-0.30至0.01；p=.07）。
■我们的研究证明了阿司匹林在经宫颈切除粘连后的中度和重度宫腔粘连中对子宫动脉血流和子宫内膜的影响。然而,本综述需要来自其他随机对照试验和高质量研究的证据.需要更严格设计的研究来评估经宫颈粘连切除术后阿司匹林给药的有效性。
