PDF(Pubmed)
Abstract：
Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms. We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic. This was achieved by focusing on a small percentage (0.9%) of total leukocytes that exhibited a higher side scatter and brighter CD19/CD20 than the remaining lymphocytes. A bone marrow aspirate three weeks later confirmed the presence of malignant B-cells. Shortly after, the patient presented splenomegaly and complained of fatigue.
摘要：
毛细胞白血病是一种罕见的白血病，一旦患者出现症状，可以通过显微镜和流式细胞术识别。我们提出了一个病例，在患者出现症状之前很久，就使用流式细胞术实现了早期诊断。这通过关注小百分比(0.9%)的总白细胞来实现,所述总白细胞表现出比剩余淋巴细胞更高的侧向散射和更亮的CD19/CD20。三周后，骨髓穿刺液证实存在恶性B细胞。不久之后,患者表现为脾肿大并抱怨疲劳。
