This is a systematic review and meta-analysis of studies using cardiopulmonary exercise testing (CPET) to examine differences in determinants of CRF between patients with JIA vs healthy controls. The primary outcome was peak oxygen uptake (VO2peak). Literature search involved PubMed, Web of Science and Scopus databases, manual search of article references and grey literature. Quality assessment was undertaken with Newcastle-Ottawa Scale.
From 480 literature records initially retrieved, eight studies (538 participants) were included in final meta-analysis. VO2peak was significantly lower in patients with JIA compared with controls [weighted mean difference (WMD): -5.95 ml/kg/min (95% CI -9.26, -2.65)]. Exercise duration and VO2peak (% predicted) were found to be significantly impaired in patients with JIA compared with controls [standardized mean difference: -0.67 (95% CI -1.04, -0.29) and WMD: -11.31% (95% CI -20.09, -2.53), respectively], while no significant differences were found in maximum heart rate.
VO2peak and other CPET variables were lower in patients with JIA compared with controls, indicating reduced CRF in the former. Overall, exercise programs for patients with JIA should be promoted as part of their treatment to improve physical fitness and reduce muscle atrophy.
CRD42022380833.
方法:这是对使用心肺运动试验(CPET)的研究的系统评价和荟萃分析,以检查JIA患者与健康对照组之间CRF决定因素的差异。主要结果是峰值摄氧量(VO2peak)。文献检索涉及PubMed,WebofScience和Scopus数据库,手动搜索文章参考文献和灰色文献。采用纽卡斯尔-渥太华量表进行质量评估。
结果:从最初检索的480个文献记录中,8项研究(538名参与者)纳入最终荟萃分析.与对照组相比,JIA患者的VO2峰值显着降低[加权平均差异(WMD):-5.95ml/kg/min(95%CI-9.26,-2.65)]。与对照组相比,JIA患者的运动持续时间和VO2峰值(预测百分比)显着受损[标准化平均差:-0.67(95%CI-1.04,-0.29)和WMD:-11.31%(95%CI-20.09,-2.53),分别],而最大心率没有发现显着差异。
结论:与对照组相比,JIA患者的VO2peak和其他CPET变量较低,表明前者的CRF降低。总的来说,应推广JIA患者的运动计划,作为其治疗的一部分,以改善身体素质并减少肌肉萎缩。
■CRD42022380833。