Abstract：
Among various nanocarriers, liposomes, and micelles are relatively mature drug delivery systems with the advantages of prolonging drug half-life, reducing toxicity, and improving efficacy. However, both have problems, such as poor stability and insufficient targeting. To further exploit the excellent properties of micelles and liposomes and avoid their shortcomings, researchers have developed new drug delivery systems by combining the two and making use of their respective advantages to achieve the goals of increasing the drug loading capacity, multiple targeting, and multiple drug delivery. The results have demonstrated that this new combination approach is a very promising delivery platform. In this paper, we review the combination strategies, preparation methods, and applications of micelles and liposomes to introduce the research progress, advantages, and challenges of composite carriers.
摘要：
在各种纳米载体中，脂质体，和胶束是相对成熟的药物传递系统，具有延长药物半衰期的优点，减少毒性，提高疗效。然而,两者都有问题,例如稳定性差和针对性不足。为了进一步开发胶束和脂质体的优异性能，避免它们的缺点，研究人员通过将两者结合并利用各自的优势来开发出新的药物递送系统，以实现增加药物装载能力的目标，多目标,和多种药物递送。结果表明，这种新的组合方法是一个非常有前途的交付平台。在本文中,我们回顾了组合策略，制备方法,并介绍了胶束和脂质体的研究进展,优势,以及复合载体的挑战。
