PDF(Pubmed)
Abstract：
BACKGROUND: Acute cerebellar ataxia (ACA) and acute cerebellitis represent disorders characterized by a para-infectious, post-infectious, or post-vaccination cerebellar inflammation. They are relatively common neurologic disorders among children, and may follow infections, or, more rarely, vaccinations. Few cases are instead described among infants. Although the immunization with meningococcal group B (MenB) vaccine has been associated with some neurological side effects, suspected ACA has been reported only once in the literature.
METHODS: we describe a 7-month-old female that presented ACA within 24 h from the MenB second dose vaccination. Extensive laboratory studies and magnetic resonance imaging excluded other causes. We then conducted an extended review of other vaccine related cases reported in the literature, focusing on the clinical characteristics of ACA and finding that ataxia and cerebellitis of para- or post-infectious cause are very rarely described in the first year of life. We collected 20 articles published in the last 30 years, including an amount of 1663 patients (1-24 years) with ACA.
CONCLUSIONS: a very small number of suspected post-vaccinal ataxias has been described in recent years, compared to other causes, and vaccination remains an unquestionable medical need. Further research is needed to clarify the complex pathogenesis of this disorder and its eventual link with vaccinations.
METHODS: we describe a 7-month-old female that presented ACA within 24 h from the MenB second dose vaccination. Extensive laboratory studies and magnetic resonance imaging excluded other causes. We then conducted an extended review of other vaccine related cases reported in the literature, focusing on the clinical characteristics of ACA and finding that ataxia and cerebellitis of para- or post-infectious cause are very rarely described in the first year of life. We collected 20 articles published in the last 30 years, including an amount of 1663 patients (1-24 years) with ACA.
CONCLUSIONS: a very small number of suspected post-vaccinal ataxias has been described in recent years, compared to other causes, and vaccination remains an unquestionable medical need. Further research is needed to clarify the complex pathogenesis of this disorder and its eventual link with vaccinations.
摘要：
背景：急性小脑共济失调（ACA）和急性小脑炎代表以副感染为特征的疾病，感染后，或疫苗接种后小脑炎症。它们是儿童中相对常见的神经系统疾病，并可能跟随感染，或者，很少,疫苗接种。相反，在婴儿中很少描述病例。尽管B群脑膜炎球菌（MenB）疫苗的免疫接种与一些神经系统副作用有关，疑似ACA在文献中只报道过一次。
方法：我们描述了一名7个月大的女性，在MenB第二剂疫苗接种后24小时内出现ACA。广泛的实验室研究和磁共振成像排除了其他原因。然后，我们对文献中报道的其他疫苗相关病例进行了扩展审查，重点关注ACA的临床特征，并发现在出生后的第一年很少描述感染副或感染后原因的共济失调和小脑炎。我们收集了过去30年发表的20篇文章，包括1663例（1-24岁）ACA患者。
结论：近年来已经描述了极少数可疑的疫苗接种后共济失调，与其他原因相比，和疫苗接种仍然是一个毫无疑问的医疗需求。需要进一步的研究来阐明这种疾病的复杂发病机理及其与疫苗接种的最终联系。
方法：我们描述了一名7个月大的女性，在MenB第二剂疫苗接种后24小时内出现ACA。广泛的实验室研究和磁共振成像排除了其他原因。然后，我们对文献中报道的其他疫苗相关病例进行了扩展审查，重点关注ACA的临床特征，并发现在出生后的第一年很少描述感染副或感染后原因的共济失调和小脑炎。我们收集了过去30年发表的20篇文章，包括1663例（1-24岁）ACA患者。
结论：近年来已经描述了极少数可疑的疫苗接种后共济失调，与其他原因相比，和疫苗接种仍然是一个毫无疑问的医疗需求。需要进一步的研究来阐明这种疾病的复杂发病机理及其与疫苗接种的最终联系。
