Abstract：
Scarce data explored the associations of apolipoproteins with hemoglobin glycation index (HGI) and triglyceride-glucose (TyG) index. This study determined associations of serum apolipoproteinA1 (ApoA1) and high density lipoprotein cholesterol (HDL-C) with HGI and TyG index in coronary artery disease (CAD) patients.
A total of 10,803 CAD patients were included in this cross-sectional pilot study. Serum concentrations of ApoA1 and HDL-C were measured. Analyses of covariance were used to compare the mean differences in glucose metabolism indices (e.g., HGI, TyG index, hemoglobin glycation [HbA1c], fasting blood glucose [FBG]) among the quartiles of ApoA1, HDL-C and HDL-C/ApoA1 ratio.
In multivariate analysis, higher ApoA1, HDL-C and HDL-C/ApoA1 ratio were associated with significantly lower HGI (Quartile [Q]4 vs. Q1: -0.032 % vs. 0.017 % for ApoA1; -0.072 % vs. 0.079 % for HDL-C; -0.083 % vs. 0.085 % for HDL-C/ApoA1 ratio). Intermediate ApoA1 level was inversely associated with TyG index (Q2 vs. Q1: 296.278 vs. 306.794). The mean TyG index were significantly decreased with increased HDL-C and HDL-C/ApoA1 ratio (Q4 vs. Q1: 298.584 vs. 309.221 for HDL-C; 300.405 vs. 315.218 for HDL-C/ApoA1 ratio). Moreover, the inverse associations of ApoA1, HDL-C and HDL-C/ApoA1 ratio with HbA1c and FBG also were observed. In path analysis, the associations of HDL-C and HDL-C/ApoA1 ratio with TyG index were mediated by obesity.
This study provided further support for the hypoglycemic effects of ApoA1 and HDL-C in patients with CAD. Replication of these findings is warranted in further longitudinal studies in different populations.
A total of 10,803 CAD patients were included in this cross-sectional pilot study. Serum concentrations of ApoA1 and HDL-C were measured. Analyses of covariance were used to compare the mean differences in glucose metabolism indices (e.g., HGI, TyG index, hemoglobin glycation [HbA1c], fasting blood glucose [FBG]) among the quartiles of ApoA1, HDL-C and HDL-C/ApoA1 ratio.
In multivariate analysis, higher ApoA1, HDL-C and HDL-C/ApoA1 ratio were associated with significantly lower HGI (Quartile [Q]4 vs. Q1: -0.032 % vs. 0.017 % for ApoA1; -0.072 % vs. 0.079 % for HDL-C; -0.083 % vs. 0.085 % for HDL-C/ApoA1 ratio). Intermediate ApoA1 level was inversely associated with TyG index (Q2 vs. Q1: 296.278 vs. 306.794). The mean TyG index were significantly decreased with increased HDL-C and HDL-C/ApoA1 ratio (Q4 vs. Q1: 298.584 vs. 309.221 for HDL-C; 300.405 vs. 315.218 for HDL-C/ApoA1 ratio). Moreover, the inverse associations of ApoA1, HDL-C and HDL-C/ApoA1 ratio with HbA1c and FBG also were observed. In path analysis, the associations of HDL-C and HDL-C/ApoA1 ratio with TyG index were mediated by obesity.
This study provided further support for the hypoglycemic effects of ApoA1 and HDL-C in patients with CAD. Replication of these findings is warranted in further longitudinal studies in different populations.
摘要：
目的：研究了载脂蛋白与血红蛋白糖化指数（HGI）和甘油三酯-葡萄糖指数（TyG）的相关性。这项研究确定了冠心病（CAD）患者血清载脂蛋白A1（ApoA1）和高密度脂蛋白胆固醇（HDL-C）与HGI和TyG指数的关系。
方法：共有10,803名CAD患者纳入本横断面试验研究。测定ApoA1和HDL-C的血清浓度。协方差分析用于比较葡萄糖代谢指标的平均差异(例如，HGI,TyG指数,血红蛋白糖化[HbA1c]，空腹血糖[FBG]）在ApoA1，HDL-C和HDL-C/ApoA1比率的四分位数中。
结果：在多变量分析中，较高的ApoA1，HDL-C和HDL-C/ApoA1比率与显着较低的HGI相关（四分[Q]4与Q1：-0.032%vs.ApoA1为0.017%；-0.072%与HDL-C为0.079%；-0.083%vs.HDL-C/ApoA1比值为0.085%)。中间ApoA1水平与TyG指数呈负相关（Q2与Q1:296.278vs.306.794)。随着HDL-C和HDL-C/ApoA1比率的增加，平均TyG指数显着降低（Q4与Q1:298.584vs.HDL-C为309.221；300.405与HDL-C/ApoA1比率为315.218)。此外，ApoA1,HDL-C和HDL-C/ApoA1比值与HbA1c和FBG呈负相关.在路径分析中，HDL-C和HDL-C/ApoA1比值与TyG指数的相关性由肥胖介导.
结论：本研究进一步支持ApoA1和HDL-C对CAD患者的降血糖作用。在不同人群的进一步纵向研究中，有必要复制这些发现。
方法：共有10,803名CAD患者纳入本横断面试验研究。测定ApoA1和HDL-C的血清浓度。协方差分析用于比较葡萄糖代谢指标的平均差异(例如，HGI,TyG指数,血红蛋白糖化[HbA1c]，空腹血糖[FBG]）在ApoA1，HDL-C和HDL-C/ApoA1比率的四分位数中。
结果：在多变量分析中，较高的ApoA1，HDL-C和HDL-C/ApoA1比率与显着较低的HGI相关（四分[Q]4与Q1：-0.032%vs.ApoA1为0.017%；-0.072%与HDL-C为0.079%；-0.083%vs.HDL-C/ApoA1比值为0.085%)。中间ApoA1水平与TyG指数呈负相关（Q2与Q1:296.278vs.306.794)。随着HDL-C和HDL-C/ApoA1比率的增加，平均TyG指数显着降低（Q4与Q1:298.584vs.HDL-C为309.221；300.405与HDL-C/ApoA1比率为315.218)。此外，ApoA1,HDL-C和HDL-C/ApoA1比值与HbA1c和FBG呈负相关.在路径分析中，HDL-C和HDL-C/ApoA1比值与TyG指数的相关性由肥胖介导.
结论：本研究进一步支持ApoA1和HDL-C对CAD患者的降血糖作用。在不同人群的进一步纵向研究中，有必要复制这些发现。
