PDF(Pubmed)
Abstract：
OBJECTIVE: The primary aim of this qualitative study was to delineate psychological mechanisms of change in the first randomized controlled trial of psilocybin-assisted psychotherapy to treat alcohol use disorder (AUD). Theories regarding psychological processes involved in psychedelic therapy remain underdeveloped.
METHODS: Participants (N = 13) mostly identified as non-Hispanic and White, with approximately equal proportions of cisgender men and women. Participants engaged in semistructured interviews about their subjective experiences in the study. Questions probed the nature of participants\' drinking before and after the study as well as coping patterns in response to strong emotions, stress, and cravings for alcohol. Verbatim transcripts were coded using Dedoose software, and content was analyzed with interpretive phenomenological analysis.
RESULTS: Participants reported that the psilocybin treatment helped them process emotions related to painful past events and helped promote states of self-compassion, self-awareness, and feelings of interconnectedness. The acute states during the psilocybin sessions were described as laying the foundation for developing more self-compassionate regulation of negative affect. Participants also described newfound feelings of belonging and an improved quality of relationships following the treatment.
CONCLUSIONS: Our results support the assertion that psilocybin increases the malleability of self-related processing, and diminishes shame-based and self-critical thought patterns while improving affect regulation and reducing alcohol cravings. These findings suggest that psychosocial treatments that integrate self-compassion training with psychedelic therapy may serve as a useful tool for enhancing psychological outcomes in the treatment of AUD. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
METHODS: Participants (N = 13) mostly identified as non-Hispanic and White, with approximately equal proportions of cisgender men and women. Participants engaged in semistructured interviews about their subjective experiences in the study. Questions probed the nature of participants\' drinking before and after the study as well as coping patterns in response to strong emotions, stress, and cravings for alcohol. Verbatim transcripts were coded using Dedoose software, and content was analyzed with interpretive phenomenological analysis.
RESULTS: Participants reported that the psilocybin treatment helped them process emotions related to painful past events and helped promote states of self-compassion, self-awareness, and feelings of interconnectedness. The acute states during the psilocybin sessions were described as laying the foundation for developing more self-compassionate regulation of negative affect. Participants also described newfound feelings of belonging and an improved quality of relationships following the treatment.
CONCLUSIONS: Our results support the assertion that psilocybin increases the malleability of self-related processing, and diminishes shame-based and self-critical thought patterns while improving affect regulation and reducing alcohol cravings. These findings suggest that psychosocial treatments that integrate self-compassion training with psychedelic therapy may serve as a useful tool for enhancing psychological outcomes in the treatment of AUD. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
摘要：
目的：这项定性研究的主要目的是描述第一个随机对照试验中的心理变化机制，即psilocybin辅助心理治疗治疗酒精使用障碍（AUD）。有关迷幻疗法涉及的心理过程的理论仍然不发达。
方法：参与者（N=13）主要被确定为非西班牙裔和白人，男性和女性的比例大致相同。参与者就他们在研究中的主观经历进行了半结构化访谈。问题探讨了参与者在研究前后饮酒的性质，以及应对强烈情绪的应对方式，压力，和对酒精的渴望。使用Dedoose软件对逐字记录进行编码，内容进行了解释现象学分析。
结果：参与者报告说，psilocybin治疗帮助他们处理与痛苦的过去事件有关的情绪，并有助于促进自我同情状态，自我意识,和相互联系的感觉。psilocybin会议期间的急性状态被描述为发展更多的自我同情调节负面影响奠定了基础。参与者还描述了治疗后新发现的归属感和改善的人际关系质量。
结论：我们的结果支持psilocybin增加自我相关加工的延展性的断言，并减少基于羞耻和自我批评的思维模式，同时改善影响调节和减少对酒精的渴望。这些发现表明，将自我同情训练与迷幻疗法相结合的社会心理疗法可能是增强AUD治疗心理结果的有用工具。(PsycInfo数据库记录(c)2023年APA，保留所有权利)。
方法：参与者（N=13）主要被确定为非西班牙裔和白人，男性和女性的比例大致相同。参与者就他们在研究中的主观经历进行了半结构化访谈。问题探讨了参与者在研究前后饮酒的性质，以及应对强烈情绪的应对方式，压力，和对酒精的渴望。使用Dedoose软件对逐字记录进行编码，内容进行了解释现象学分析。
结果：参与者报告说，psilocybin治疗帮助他们处理与痛苦的过去事件有关的情绪，并有助于促进自我同情状态，自我意识,和相互联系的感觉。psilocybin会议期间的急性状态被描述为发展更多的自我同情调节负面影响奠定了基础。参与者还描述了治疗后新发现的归属感和改善的人际关系质量。
结论：我们的结果支持psilocybin增加自我相关加工的延展性的断言，并减少基于羞耻和自我批评的思维模式，同时改善影响调节和减少对酒精的渴望。这些发现表明，将自我同情训练与迷幻疗法相结合的社会心理疗法可能是增强AUD治疗心理结果的有用工具。(PsycInfo数据库记录(c)2023年APA，保留所有权利)。
