Abstract：
OBJECTIVE: This study aimed to estimate aspiration pneumonia (AP) incidence and describe comorbid characteristics and mortality in Beijing, China.
METHODS: A historical cohort study was conducted based on medical claim records.
METHODS: Patients admitted with a primary diagnosis of AP were identified from approximately 12 million adults who enrolled in the Urban Employee Basic Medical Insurance program in Beijing, China, from January 2011 to December 2017. The incidences of AP and pneumonia with risk factors for aspiration (PRFA) were estimated by a Poisson distribution. The estimated annual percentage change was reported to represent the average percentage change in incidence per year. Characteristics and 6-month and 1-year all-cause mortality rates for AP and suspected AP patients were described and compared with community-acquired pneumonia (CAP).
RESULTS: The incidence rates of hospitalized AP and PRFA were 9.4 (95% confidence interval [CI]: 7.6, 11.3) and 102.9 (95% CI: 95.8, 110.3) per 100,000 person-years, respectively. The incidences increased rapidly with age and were stable across the observed years. Patients with AP and PRFA possessed a greater burden of comorbidities than CAP (mean age-adjusted Charlson comorbidity indices for AP: 7.72, PRFA: 7.83, and CAP: 2.84). The 6-month and 1-year all-cause mortality rates for those with AP and PRFA were higher than those for patients with CAP (6-month mortality, AP: 35.2%, PRFA: 21.8%, CAP: 11.1%; 1-year mortality, AP: 42.7%, PRFA: 26.6%, CAP: 13.2%).
CONCLUSIONS: The incidence of AP and PRFA in Beijing was reported, presenting a full picture of the disease burden. The results provide baseline information for AP prevention.
METHODS: A historical cohort study was conducted based on medical claim records.
METHODS: Patients admitted with a primary diagnosis of AP were identified from approximately 12 million adults who enrolled in the Urban Employee Basic Medical Insurance program in Beijing, China, from January 2011 to December 2017. The incidences of AP and pneumonia with risk factors for aspiration (PRFA) were estimated by a Poisson distribution. The estimated annual percentage change was reported to represent the average percentage change in incidence per year. Characteristics and 6-month and 1-year all-cause mortality rates for AP and suspected AP patients were described and compared with community-acquired pneumonia (CAP).
RESULTS: The incidence rates of hospitalized AP and PRFA were 9.4 (95% confidence interval [CI]: 7.6, 11.3) and 102.9 (95% CI: 95.8, 110.3) per 100,000 person-years, respectively. The incidences increased rapidly with age and were stable across the observed years. Patients with AP and PRFA possessed a greater burden of comorbidities than CAP (mean age-adjusted Charlson comorbidity indices for AP: 7.72, PRFA: 7.83, and CAP: 2.84). The 6-month and 1-year all-cause mortality rates for those with AP and PRFA were higher than those for patients with CAP (6-month mortality, AP: 35.2%, PRFA: 21.8%, CAP: 11.1%; 1-year mortality, AP: 42.7%, PRFA: 26.6%, CAP: 13.2%).
CONCLUSIONS: The incidence of AP and PRFA in Beijing was reported, presenting a full picture of the disease burden. The results provide baseline information for AP prevention.
摘要：
目的：本研究旨在评估北京吸入性肺炎（AP）的发病率并描述合并症特征和死亡率，中国。
方法：根据医疗索赔记录进行了一项历史队列研究。
方法：从北京参加城镇职工基本医疗保险计划的大约1200万成年人中确定了确诊为AP的患者。中国,2011年1月至2017年12月。通过泊松分布估计具有误吸危险因素（PRFA）的AP和肺炎的发生率。据报告，估计的年度百分比变化代表了每年发病率的平均百分比变化。描述了AP和疑似AP患者的特征以及6个月和1年全因死亡率，并与社区获得性肺炎（CAP）进行了比较。
结果：住院AP和PRFA的发生率分别为9.4（95％置信区间[CI]：7.6，11.3）和102.9（95％CI：95.8，110.3）每100,000人年，分别。发病率随着年龄的增长而迅速增加，并且在观察到的年份中保持稳定。与CAP相比，AP和PRFA患者的合并症负担更大（AP的平均年龄校正Charlson合并症指数：7.72，PRFA：7.83和CAP：2.84）。AP和PRFA患者的6个月和1年全因死亡率高于CAP患者（6个月死亡率，AP：35.2％，PRFA：21.8%，CAP：11.1%；1年死亡率，AP：42.7％，PRFA:26.6%,CAP：13.2%）。
结论：报告了北京AP和PRFA的发病率，呈现疾病负担的全貌。结果为AP预防提供了基线信息。
方法：根据医疗索赔记录进行了一项历史队列研究。
方法：从北京参加城镇职工基本医疗保险计划的大约1200万成年人中确定了确诊为AP的患者。中国,2011年1月至2017年12月。通过泊松分布估计具有误吸危险因素（PRFA）的AP和肺炎的发生率。据报告，估计的年度百分比变化代表了每年发病率的平均百分比变化。描述了AP和疑似AP患者的特征以及6个月和1年全因死亡率，并与社区获得性肺炎（CAP）进行了比较。
结果：住院AP和PRFA的发生率分别为9.4（95％置信区间[CI]：7.6，11.3）和102.9（95％CI：95.8，110.3）每100,000人年，分别。发病率随着年龄的增长而迅速增加，并且在观察到的年份中保持稳定。与CAP相比，AP和PRFA患者的合并症负担更大（AP的平均年龄校正Charlson合并症指数：7.72，PRFA：7.83和CAP：2.84）。AP和PRFA患者的6个月和1年全因死亡率高于CAP患者（6个月死亡率，AP：35.2％，PRFA：21.8%，CAP：11.1%；1年死亡率，AP：42.7％，PRFA:26.6%,CAP：13.2%）。
结论：报告了北京AP和PRFA的发病率，呈现疾病负担的全貌。结果为AP预防提供了基线信息。
