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Abstract：
OBJECTIVE: The objective of this study was to investigate non-cancer causes of death and associated risk factors after bladder cancer (BC) diagnosis.
METHODS: Eligible BC patients were obtained from the SEER database. SEER*Stat software 8.3.9.2 was used to calculate the standardized mortality ratios (SMRs). The proportions of different non-cancer cause of death were calculated and analyzed in different follow-up periods. Multivariate competing risk model was used to analyze the risk factors for death of BC and non-cancer diseases.
RESULTS: In total, 240,954 BC patients were included and 106,092 patients experienced death, with 37,205 (35.07%), 13,208 (12.45%) and 55,679 (52.48%) patients experienced BC, other cancer and non-cancer disease-related deaths, respectively. Overall SMR for BC patients who died from non-cancer diseases was 2.42 (95% CI [2.40-2.44]). Cardiovascular diseases were the most common non-cancer cause of death, followed by respiratory diseases, diabetes mellitus, and infectious diseases. Multivariate competing risk analysis identified the following high-risk factors for non-cancer mortality: age > 60 years, male, whites, in situ stage, pathological type of transitional cell carcinoma, not receiving treatment (including surgery, chemotherapy, or radiation), and widowed.
CONCLUSIONS: Cardiovascular diseases are the leading non-cancer cause of death in BC patients, followed by respiratory disease, diabetes mellitus and infectious diseases. Physicians should pay attention to the risk of death from these non-cancer diseases. Also, physicians should encourage patients to engage in more proactive self-surveillance and follow up.
METHODS: Eligible BC patients were obtained from the SEER database. SEER*Stat software 8.3.9.2 was used to calculate the standardized mortality ratios (SMRs). The proportions of different non-cancer cause of death were calculated and analyzed in different follow-up periods. Multivariate competing risk model was used to analyze the risk factors for death of BC and non-cancer diseases.
RESULTS: In total, 240,954 BC patients were included and 106,092 patients experienced death, with 37,205 (35.07%), 13,208 (12.45%) and 55,679 (52.48%) patients experienced BC, other cancer and non-cancer disease-related deaths, respectively. Overall SMR for BC patients who died from non-cancer diseases was 2.42 (95% CI [2.40-2.44]). Cardiovascular diseases were the most common non-cancer cause of death, followed by respiratory diseases, diabetes mellitus, and infectious diseases. Multivariate competing risk analysis identified the following high-risk factors for non-cancer mortality: age > 60 years, male, whites, in situ stage, pathological type of transitional cell carcinoma, not receiving treatment (including surgery, chemotherapy, or radiation), and widowed.
CONCLUSIONS: Cardiovascular diseases are the leading non-cancer cause of death in BC patients, followed by respiratory disease, diabetes mellitus and infectious diseases. Physicians should pay attention to the risk of death from these non-cancer diseases. Also, physicians should encourage patients to engage in more proactive self-surveillance and follow up.
摘要：
目的：本研究的目的是调查膀胱癌（BC）诊断后的非癌症死亡原因和相关危险因素。
方法：从SEER数据库获得合格的BC患者。SEER*Stat软件8.3.9.2用于计算标准化死亡率比(SMR)。计算并分析不同随访时期不同非癌症死亡原因的比例。采用多因素竞争风险模型分析BC与非癌性疾病死亡的危险因素。
结果：总计，纳入240,954例BC患者，106,092例患者死亡，37,205（35.07%），13,208例（12.45%）和55,679例（52.48%）患者经历了BC，其他癌症和非癌症疾病相关死亡，分别。死于非癌症疾病的BC患者的总体SMR为2.42(95%CI[2.40-2.44])。心血管疾病是最常见的非癌症死亡原因，其次是呼吸系统疾病，糖尿病,和传染病。多变量竞争风险分析确定了以下非癌症死亡率的高危因素：年龄>60岁，男性,白人,原位阶段，移行细胞癌的病理类型，不接受治疗（包括手术，化疗,或辐射)，和寡妇。
结论：心血管疾病是导致BC患者死亡的主要非癌症原因，其次是呼吸道疾病，糖尿病和传染病。医生应该注意这些非癌症疾病的死亡风险。此外，医师应鼓励患者进行更积极主动的自我监测和随访.
方法：从SEER数据库获得合格的BC患者。SEER*Stat软件8.3.9.2用于计算标准化死亡率比(SMR)。计算并分析不同随访时期不同非癌症死亡原因的比例。采用多因素竞争风险模型分析BC与非癌性疾病死亡的危险因素。
结果：总计，纳入240,954例BC患者，106,092例患者死亡，37,205（35.07%），13,208例（12.45%）和55,679例（52.48%）患者经历了BC，其他癌症和非癌症疾病相关死亡，分别。死于非癌症疾病的BC患者的总体SMR为2.42(95%CI[2.40-2.44])。心血管疾病是最常见的非癌症死亡原因，其次是呼吸系统疾病，糖尿病,和传染病。多变量竞争风险分析确定了以下非癌症死亡率的高危因素：年龄>60岁，男性,白人,原位阶段，移行细胞癌的病理类型，不接受治疗（包括手术，化疗,或辐射)，和寡妇。
结论：心血管疾病是导致BC患者死亡的主要非癌症原因，其次是呼吸道疾病，糖尿病和传染病。医生应该注意这些非癌症疾病的死亡风险。此外，医师应鼓励患者进行更积极主动的自我监测和随访.
