METHODS: Eligible BC patients were obtained from the SEER database. SEER*Stat software 8.3.9.2 was used to calculate the standardized mortality ratios (SMRs). The proportions of different non-cancer cause of death were calculated and analyzed in different follow-up periods. Multivariate competing risk model was used to analyze the risk factors for death of BC and non-cancer diseases.
RESULTS: In total, 240,954 BC patients were included and 106,092 patients experienced death, with 37,205 (35.07%), 13,208 (12.45%) and 55,679 (52.48%) patients experienced BC, other cancer and non-cancer disease-related deaths, respectively. Overall SMR for BC patients who died from non-cancer diseases was 2.42 (95% CI [2.40-2.44]). Cardiovascular diseases were the most common non-cancer cause of death, followed by respiratory diseases, diabetes mellitus, and infectious diseases. Multivariate competing risk analysis identified the following high-risk factors for non-cancer mortality: age > 60 years, male, whites, in situ stage, pathological type of transitional cell carcinoma, not receiving treatment (including surgery, chemotherapy, or radiation), and widowed.
CONCLUSIONS: Cardiovascular diseases are the leading non-cancer cause of death in BC patients, followed by respiratory disease, diabetes mellitus and infectious diseases. Physicians should pay attention to the risk of death from these non-cancer diseases. Also, physicians should encourage patients to engage in more proactive self-surveillance and follow up.
方法:从SEER数据库获得合格的BC患者。SEER*Stat软件8.3.9.2用于计算标准化死亡率比(SMR)。计算并分析不同随访时期不同非癌症死亡原因的比例。采用多因素竞争风险模型分析BC与非癌性疾病死亡的危险因素。
结果:总计,纳入240,954例BC患者,106,092例患者死亡,37,205(35.07%),13,208例(12.45%)和55,679例(52.48%)患者经历了BC,其他癌症和非癌症疾病相关死亡,分别。死于非癌症疾病的BC患者的总体SMR为2.42(95%CI[2.40-2.44])。心血管疾病是最常见的非癌症死亡原因,其次是呼吸系统疾病,糖尿病,和传染病。多变量竞争风险分析确定了以下非癌症死亡率的高危因素:年龄>60岁,男性,白人,原位阶段,移行细胞癌的病理类型,不接受治疗(包括手术,化疗,或辐射),和寡妇。
结论:心血管疾病是导致BC患者死亡的主要非癌症原因,其次是呼吸道疾病,糖尿病和传染病。医生应该注意这些非癌症疾病的死亡风险。此外,医师应鼓励患者进行更积极主动的自我监测和随访.