关键词: Chronic intestinal pseudo-obstruction Colonisation bactérienne chronique du grêle Ectasie vasculaire antrale gastrique Gastric antral vascular ectasia Gastroesophageal reflux disease Pseudo-obstruction intestinale chronique Reflux gastro-œsophagien Sclérodermie systémique Small intestinal bacterial overgrowth Systemic sclerosis

Mesh : Humans Quality of Life Scleroderma, Systemic / complications diagnosis therapy Gastrointestinal Tract Malnutrition Proton Pump Inhibitors Gastrointestinal Diseases / diagnosis epidemiology etiology

来  源:   DOI:10.1016/j.revmed.2023.05.003

Abstract:
Gastrointestinal tract involvement in systemic sclerosis concerns more than 90% of patients but is of heterogeneous clinical expression. It can involve the entire intestinal tract and be responsible for multifactorial malnutrition, which is frequent in this disease. It is a major source of deterioration in the quality of life and can even be life-threatening. Management is complex and multidisciplinary, ranging from simple hygienic and dietary measures, to specialized endoscopic or surgical interventional procedures, also including medical treatments, particularly proton pump inhibitors and prokinetics, with potential side effects. Ongoing research for new diagnostic and therapeutic tools promises to improve the management and prognosis of these patients.
摘要:
系统性硬化症的胃肠道受累涉及90%以上的患者,但临床表现不均匀。它可能涉及整个肠道,并导致多因素营养不良,这在这种疾病中很常见。它是生活质量恶化的主要原因,甚至可能危及生命。管理是复杂的,多学科的,从简单的卫生和饮食措施,专门的内窥镜或外科介入程序,还包括医疗,特别是质子泵抑制剂和前动力学,有潜在的副作用。对新的诊断和治疗工具的持续研究有望改善这些患者的管理和预后。
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