PDF(Pubmed)
Abstract：
The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a \"cutaneous-gluten sensitivity,\" as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.
摘要：
术语谷蛋白相关疾病（GRD）是指在遗传易感个体中摄入谷蛋白引发的一系列不同的临床表现，包括乳糜泻（CD），小麦过敏和非乳糜泻谷蛋白敏感性（NCGS）。GRD的特征在于具有肠和肠外表现的大量临床表现。后者可能会影响身体的几乎每个器官，包括皮肤。除了众所周知的CD和疱疹样皮炎之间的关联，被认为是CD的皮肤特异性表现，许多其他粘膜皮肤疾病与GRD有关。在这次审查中,我们分析了皮肤病的主要特征与GRD和那些改善后无麸质饮食，重点关注与NCGS相关的新描述的皮肤表现。我们的主要假设是皮肤面筋敏感性，“作为NCGS的特定皮肤表现，可能存在，并可能代表NCGS的诊断标志物。
