%0 Journal Article
%T Skin gluten-related disorders: new and old cutaneous manifestations to be considered.
%A Verdelli A
%A Corrà A
%A Mariotti EB
%A Aimo C
%A Quintarelli L
%A Ruffo di Calabria V
%A Donati ME
%A Bonciolini V
%A Antiga E
%A Caproni M
%J Front Med (Lausanne)
%V 10
%N 0
%D 2023
%M 37265490
%F 5.058
%R 10.3389/fmed.2023.1155288
%X The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a "cutaneous-gluten sensitivity," as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.