PDF(Pubmed)
Abstract：
Ethnopharmacology has been an important starting point in medical and pharmaceutical sciences for discovering drug candidates from natural sources. In this regard, the genus Salvia L., commonly known as sage, is one of the best-known medicinal and aromatic plants of the Lamiaceae family; it has been recorded as being used for memory enhancement in European folk medicine. Despite the various uses of sage in folk medicines, the records that have pointed out sage\'s memory-enhancing properties have paved the way for the aforementioned effect to be proven on scientific grounds. There are many preclinical studies and excellent reviews referring to the favorable effect of different species of sage against the cognitive dysfunction that is related to Alzheimer\'s disease (AD). Hence, the current review discusses clinical studies that provide evidence for the effect of Salvia species on cognitive dysfunction. Clinical studies have shown that some Salvia species, i.e., hydroalcoholic extracts and essential oils of S. officinalis L. and S. lavandulaefolia leaves in particular, have been the most prominently effective species in patients with mild to moderate AD, and these species have shown positive effects on the memory of young and healthy people. However, the numbers of subjects in the studies were small, and standardized extracts were not used for the most part. Our review points out to the need for longer-term clinical studies with higher numbers of subjects being administered standardized sage preparations.
摘要：
民族药理学一直是医学和制药科学中从天然来源发现候选药物的重要起点。在这方面,丹参属，通常被称为鼠尾草，是唇形科最著名的药用和芳香植物之一；它已被记录为在欧洲民间医学中用于增强记忆。尽管鼠尾草在民间药物中有各种用途，这些记录指出了鼠尾草的记忆增强特性，为在科学基础上证明上述效果铺平了道路。有许多临床前研究和优秀的评论提到不同种类的鼠尾草对与阿尔茨海默病（AD）相关的认知功能障碍的有利作用。因此，本综述讨论了为丹参物种对认知功能障碍的影响提供证据的临床研究。临床研究表明，一些丹参物种，即，水醇提取物和精油，特别是S.lavandulafolia叶，在轻度至中度AD患者中，这些物种对年轻人和健康人的记忆表现出积极的影响。然而,研究中的受试者数量很少，和标准化的提取物大部分没有使用。我们的评论指出，需要更多的受试者接受标准化鼠尾草制剂的长期临床研究。
