PDF(Pubmed)
Abstract：
We herein report three cases of steroid-resistant nephrotic syndrome successfully treated with low-density lipoprotein apheresis (LDL-A). All patients were treated with a combination of steroids, cyclosporine, and LDL-A. In all cases, the serum concentrations of LDL, total and high-density lipoprotein cholesterol, and triglycerides were significantly lowered following LDL-A administration. Furthermore, the estimated LDL receptor activity increased, while both serum LDL and total cholesterol levels decreased, suggesting that LDL-A increases LDL receptor activity by driving changes in serum cholesterol concentration. This case series suggests that LDL-A increases LDL receptor activity, which may improve the intracellular uptake of cyclosporine.
摘要：
我们在此报告了三例成功接受低密度脂蛋白单采术（LDL-A）治疗的类固醇抗性肾病综合征。所有患者都接受了类固醇的联合治疗，环孢菌素,LDL-A在所有情况下,LDL的血清浓度，总胆固醇和高密度脂蛋白胆固醇，LDL-A给药后甘油三酯显著降低。此外，估计的LDL受体活性增加，而血清LDL和总胆固醇水平均下降，提示LDL-A通过驱动血清胆固醇浓度的变化而增加LDL受体活性。这个案例系列表明LDL-A增加LDL受体活性，这可能会改善细胞内对环孢菌素的摄取。
