{Reference Type}: Journal Article
{Title}: Low-density Lipoprotein Receptor Activities, Lipids, Apolipoprotein, and Clinical Course of Patients with Steroid-resistant Nephrotic Syndrome Treated with Low-density Lipoprotein Apheresis: A Case Series.
{Author}: Shima H;Higashiguchi Y;Doi T;Harada M;Okamoto T;Inoue T;Tashiro M;Okada K;Minakuchi J;
{Journal}: Intern Med
{Volume}: 63
{Issue}: 3
{Year}: 2024 Feb 1
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.1922-23
{Abstract}: We herein report three cases of steroid-resistant nephrotic syndrome successfully treated with low-density lipoprotein apheresis (LDL-A). All patients were treated with a combination of steroids, cyclosporine, and LDL-A. In all cases, the serum concentrations of LDL, total and high-density lipoprotein cholesterol, and triglycerides were significantly lowered following LDL-A administration. Furthermore, the estimated LDL receptor activity increased, while both serum LDL and total cholesterol levels decreased, suggesting that LDL-A increases LDL receptor activity by driving changes in serum cholesterol concentration. This case series suggests that LDL-A increases LDL receptor activity, which may improve the intracellular uptake of cyclosporine.