PDF(Pubmed)
Abstract：
UNASSIGNED: The contribution of inactive Matrix Gla protein (MGP) to ectopic vascular calcification associated with type 2 diabetes mellitus (T2DM) is well recognized. However, its role in diabetic microvascular complications remains unknown. The study aim was to identify any association between inactive MGP and diabetic retinopathy (DR). Its relation to insulin resistance was also explored.
UNASSIGNED: The study included 90 participants, 65 Type 2 diabetic patients (25 without DR and 40 with DR) and 25 healthy controls. Serum inactive MGP was measured using ELISA. HOMA-IR was also assessed.
UNASSIGNED: Inactive MGP was significantly higher in both diabetic groups compared to controls (P < 0.001), as well as in Type 2 diabetic patients with retinopathy compared to Type 2 diabetes without retinopathy (P = 0.002). Inactive MGP was positively correlated with HbA1c, HOMA-IR, LDL-C and triglycerides (P < 0.001), and negatively correlated with HDL-C (P = 0.008) and eGFR (P < 0.001). Logistic Regression Analysis showed that inactive MGP was one of the most associated factors with DR.
UNASSIGNED: Inactive MGP was found to be related to DR, insulin resistance and other dysmetabolic risk factors. These findings highlight that inactive MGP may be a significant contributor to the pathogenesis, evolution, and progression of DR.
UNASSIGNED: The study included 90 participants, 65 Type 2 diabetic patients (25 without DR and 40 with DR) and 25 healthy controls. Serum inactive MGP was measured using ELISA. HOMA-IR was also assessed.
UNASSIGNED: Inactive MGP was significantly higher in both diabetic groups compared to controls (P < 0.001), as well as in Type 2 diabetic patients with retinopathy compared to Type 2 diabetes without retinopathy (P = 0.002). Inactive MGP was positively correlated with HbA1c, HOMA-IR, LDL-C and triglycerides (P < 0.001), and negatively correlated with HDL-C (P = 0.008) and eGFR (P < 0.001). Logistic Regression Analysis showed that inactive MGP was one of the most associated factors with DR.
UNASSIGNED: Inactive MGP was found to be related to DR, insulin resistance and other dysmetabolic risk factors. These findings highlight that inactive MGP may be a significant contributor to the pathogenesis, evolution, and progression of DR.
摘要：
■无活性的基质Gla蛋白（MGP）对与2型糖尿病（T2DM）相关的异位血管钙化的贡献是公认的。然而,其在糖尿病微血管并发症中的作用尚不清楚。该研究的目的是确定非活性MGP与糖尿病性视网膜病变（DR）之间的任何关联。还探讨了其与胰岛素抵抗的关系。
■该研究包括90名参与者，65例2型糖尿病患者（25例无DR，40例有DR）和25例健康对照。使用ELISA测量血清非活性MGP。还评估了HOMA-IR。
■无活性MGP在两个糖尿病组明显高于对照组（P<0.001），以及2型糖尿病患者的视网膜病变与无视网膜病变的2型糖尿病患者相比（P=0.002）。无活性MGP与HbA1c呈正相关,HOMA-IR,LDL-C和甘油三酯（P<0.001），与HDL-C(P=0.008)和eGFR(P<0.001)呈负相关。Logistic回归分析显示，不活跃的MGP是与DR最相关的因素之一。
■发现非活动MGP与DR有关，胰岛素抵抗和其他代谢异常危险因素。这些发现强调，不活跃的MGP可能是发病机理的重要因素。进化,以及DR的进展。
■该研究包括90名参与者，65例2型糖尿病患者（25例无DR，40例有DR）和25例健康对照。使用ELISA测量血清非活性MGP。还评估了HOMA-IR。
■无活性MGP在两个糖尿病组明显高于对照组（P<0.001），以及2型糖尿病患者的视网膜病变与无视网膜病变的2型糖尿病患者相比（P=0.002）。无活性MGP与HbA1c呈正相关,HOMA-IR,LDL-C和甘油三酯（P<0.001），与HDL-C(P=0.008)和eGFR(P<0.001)呈负相关。Logistic回归分析显示，不活跃的MGP是与DR最相关的因素之一。
■发现非活动MGP与DR有关，胰岛素抵抗和其他代谢异常危险因素。这些发现强调，不活跃的MGP可能是发病机理的重要因素。进化,以及DR的进展。
