UNASSIGNED: The study included 90 participants, 65 Type 2 diabetic patients (25 without DR and 40 with DR) and 25 healthy controls. Serum inactive MGP was measured using ELISA. HOMA-IR was also assessed.
UNASSIGNED: Inactive MGP was significantly higher in both diabetic groups compared to controls (P < 0.001), as well as in Type 2 diabetic patients with retinopathy compared to Type 2 diabetes without retinopathy (P = 0.002). Inactive MGP was positively correlated with HbA1c, HOMA-IR, LDL-C and triglycerides (P < 0.001), and negatively correlated with HDL-C (P = 0.008) and eGFR (P < 0.001). Logistic Regression Analysis showed that inactive MGP was one of the most associated factors with DR.
UNASSIGNED: Inactive MGP was found to be related to DR, insulin resistance and other dysmetabolic risk factors. These findings highlight that inactive MGP may be a significant contributor to the pathogenesis, evolution, and progression of DR.
■该研究包括90名参与者,65例2型糖尿病患者(25例无DR,40例有DR)和25例健康对照。使用ELISA测量血清非活性MGP。还评估了HOMA-IR。
■无活性MGP在两个糖尿病组明显高于对照组(P<0.001),以及2型糖尿病患者的视网膜病变与无视网膜病变的2型糖尿病患者相比(P=0.002)。无活性MGP与HbA1c呈正相关,HOMA-IR,LDL-C和甘油三酯(P<0.001),与HDL-C(P=0.008)和eGFR(P<0.001)呈负相关。Logistic回归分析显示,不活跃的MGP是与DR最相关的因素之一。
■发现非活动MGP与DR有关,胰岛素抵抗和其他代谢异常危险因素。这些发现强调,不活跃的MGP可能是发病机理的重要因素。进化,以及DR的进展。