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Abstract：
UNASSIGNED: The occurrence of hybrid odontogenic lesions with two or more morphologically distinct components is a rare phenomenon and poses a diagnostic challenge. We aimed to study the clinical, radiological, and pathological features and behavior of hybrid odontogenic lesions, to enhance awareness about these rare lesions.
UNASSIGNED: Hematoxylin and Eosin slides of hybrid odontogenic lesions diagnosed between January 01, 2012 and December 31, 2020, were reviewed. Demographic and radiological information were obtained from the patient\'s medical records.
UNASSIGNED: 8 cases were diagnosed with a mean age of 19.1 years and male to female ratio of 1:1.7. Involvement of mandible was more common (n = 5) as compared to maxilla (n = 3). All patients presented with swelling for an average of 9.75 months (3-25 months) duration. Bleeding, loose teeth, pain and facial asymmetry were reported in 5,3, 3, and 2 cases, respectively. Radiologically, 7 cases were well demarcated, 75% cases (n = 6) were radiolucent, and average radiological size was 4.8 cm. All patients were managed with surgery alone. 5 cases (62.5%) underwent enucleation and curettage, while local excision, en-block resection and segmental mandibulectomy were performed in 1 case each. Histologically, ossifying fibroma/cemento-ossifyiong fibroma were the most lesion, occurring in 5 cases (62%), followed by giant cell granuloma like lesions (GCG) i.e., central and peripheral giant cell granuloma (n = 3), Adenomatoid Odontogenic tumor (AOT) (n = 2), and DC (n = 2), ameloblastic fibroma (AF) (n = 1), Ameloblastoma (n = 1), calcifying odontogenic cyst (COC) (n = 1), and complex odontoma (n = 1). No evidence of recurrence was noted after 4-99 months of surgery (mean: 32.9) in cases with available data (n = 7). Long-term complaints included facial asymmetry (n = 2) and pain (n = 1).
UNASSIGNED: Most hybrid odontogenic lesions affect young females in the second decade of life and commonly show COF and OF as hybrid components. A conservative approach to management appears adequate.
UNASSIGNED: Hematoxylin and Eosin slides of hybrid odontogenic lesions diagnosed between January 01, 2012 and December 31, 2020, were reviewed. Demographic and radiological information were obtained from the patient\'s medical records.
UNASSIGNED: 8 cases were diagnosed with a mean age of 19.1 years and male to female ratio of 1:1.7. Involvement of mandible was more common (n = 5) as compared to maxilla (n = 3). All patients presented with swelling for an average of 9.75 months (3-25 months) duration. Bleeding, loose teeth, pain and facial asymmetry were reported in 5,3, 3, and 2 cases, respectively. Radiologically, 7 cases were well demarcated, 75% cases (n = 6) were radiolucent, and average radiological size was 4.8 cm. All patients were managed with surgery alone. 5 cases (62.5%) underwent enucleation and curettage, while local excision, en-block resection and segmental mandibulectomy were performed in 1 case each. Histologically, ossifying fibroma/cemento-ossifyiong fibroma were the most lesion, occurring in 5 cases (62%), followed by giant cell granuloma like lesions (GCG) i.e., central and peripheral giant cell granuloma (n = 3), Adenomatoid Odontogenic tumor (AOT) (n = 2), and DC (n = 2), ameloblastic fibroma (AF) (n = 1), Ameloblastoma (n = 1), calcifying odontogenic cyst (COC) (n = 1), and complex odontoma (n = 1). No evidence of recurrence was noted after 4-99 months of surgery (mean: 32.9) in cases with available data (n = 7). Long-term complaints included facial asymmetry (n = 2) and pain (n = 1).
UNASSIGNED: Most hybrid odontogenic lesions affect young females in the second decade of life and commonly show COF and OF as hybrid components. A conservative approach to management appears adequate.
摘要：
■具有两种或多种形态上不同成分的杂合牙源性病变的发生是一种罕见现象，并提出了诊断挑战。我们的目的是研究临床，放射学,以及杂合牙源性病变的病理特征和行为，提高对这些罕见病变的认识.
■回顾了2012年1月1日至2020年12月31日之间诊断的混合牙源性病变的苏木精和伊红载玻片。从患者的医疗记录中获得人口统计学和放射学信息。
■8例诊断为平均年龄19.1岁，男女比例为1:1.7。与上颌骨（n=3）相比，下颌骨的受累更为普遍（n=5）。所有患者出现肿胀，持续时间平均为9.75个月（3-25个月）。出血,牙齿松动,5、3、3和2例报告了疼痛和面部不对称，分别。放射学上,7例分界良好，75%的病例（n=6）是射线可透的，平均放射学大小为4.8cm。所有患者均仅接受手术治疗。5例（62.5%）行摘除术和刮宫术，而局部切除，全块切除术和节段性下颌骨切除术各1例。组织学上,骨化性纤维瘤/骨质骨化纤维瘤是最多的病变，5例（62%），其次是巨细胞肉芽肿样病变(GCG)，中央和外周巨细胞肉芽肿（n=3），腺瘤样牙源性肿瘤（AOT）（n=2），和DC(n=2)，成釉细胞纤维瘤（AF）（n=1），成釉细胞瘤（n=1），牙源性钙化囊肿（COC）（n=1），和复杂的牙瘤（n=1）。在有可用数据的情况下（n=7），手术4-99个月后（平均：32.9）没有发现复发的证据。长期主诉包括面部不对称(n=2)和疼痛(n=1)。
■大多数混合牙源性病变会在生命的第二个十年中影响年轻女性，并且通常显示COF和OF为混合成分。保守的管理方法似乎足够了。
■回顾了2012年1月1日至2020年12月31日之间诊断的混合牙源性病变的苏木精和伊红载玻片。从患者的医疗记录中获得人口统计学和放射学信息。
■8例诊断为平均年龄19.1岁，男女比例为1:1.7。与上颌骨（n=3）相比，下颌骨的受累更为普遍（n=5）。所有患者出现肿胀，持续时间平均为9.75个月（3-25个月）。出血,牙齿松动,5、3、3和2例报告了疼痛和面部不对称，分别。放射学上,7例分界良好，75%的病例（n=6）是射线可透的，平均放射学大小为4.8cm。所有患者均仅接受手术治疗。5例（62.5%）行摘除术和刮宫术，而局部切除，全块切除术和节段性下颌骨切除术各1例。组织学上,骨化性纤维瘤/骨质骨化纤维瘤是最多的病变，5例（62%），其次是巨细胞肉芽肿样病变(GCG)，中央和外周巨细胞肉芽肿（n=3），腺瘤样牙源性肿瘤（AOT）（n=2），和DC(n=2)，成釉细胞纤维瘤（AF）（n=1），成釉细胞瘤（n=1），牙源性钙化囊肿（COC）（n=1），和复杂的牙瘤（n=1）。在有可用数据的情况下（n=7），手术4-99个月后（平均：32.9）没有发现复发的证据。长期主诉包括面部不对称(n=2)和疼痛(n=1)。
■大多数混合牙源性病变会在生命的第二个十年中影响年轻女性，并且通常显示COF和OF为混合成分。保守的管理方法似乎足够了。
