PDF(Pubmed)
Abstract：
UNASSIGNED: Anatomical variations of the inner ear may contribute to the development of Ménière\'s disease (MD), which is a complex inner ear disorder histopathologically characterized by idiopathic endolymphatic hydrops (ELH). Abnormalities of the vestibular aqueduct (VA) and the jugular bulb (JB) have been suggested as predisposing factors. Yet, few studies have investigated the correlation between JB abnormalities and VA variations as well as its clinical relevance in these patients. In this retrospective study, we investigated the differences in the incidence of radiological abnormalities of the VA and JB in patients with definite MD.
UNASSIGNED: Anatomical variations of JB and VA were evaluated based on high-resolution CT (HRCT) in a series of 103 patients with MD (93 unilateral cases and 10 bilateral cases). JB-related indices included JB anteroposterior and mediolateral diameter, JB height, JB type regarding to Manjila classification system, and incidences of JB diverticulum (JBD), JB related inner ear dehiscence (JBID), and inner ear adjacent JB (IAJB). VA-related indices included CT-VA visibility, CT-VA morphology (funnel, tubular, filiform, hollow, and obliterated-shaped type), and peri-VA pneumatization. Radiological indices were compared between MD ears and control ears.
UNASSIGNED: Radiological JB abnormalities were comparable between MD ears and control ears. As for VA-related indices, the CT-VA visibility was lower in MD ears than in control ears (p = 0.004). The distribution of CT-VA morphology was significantly different between MD and control ears (p = 0.013), with a higher proportion of obliterated-shaped type in MD ears (22.1%) than in control ears (6.6%).
UNASSIGNED: Compared with JB abnormalities, the anatomical variations of VA are more likely to be an anatomically predisposing factor for MD.
UNASSIGNED: Anatomical variations of JB and VA were evaluated based on high-resolution CT (HRCT) in a series of 103 patients with MD (93 unilateral cases and 10 bilateral cases). JB-related indices included JB anteroposterior and mediolateral diameter, JB height, JB type regarding to Manjila classification system, and incidences of JB diverticulum (JBD), JB related inner ear dehiscence (JBID), and inner ear adjacent JB (IAJB). VA-related indices included CT-VA visibility, CT-VA morphology (funnel, tubular, filiform, hollow, and obliterated-shaped type), and peri-VA pneumatization. Radiological indices were compared between MD ears and control ears.
UNASSIGNED: Radiological JB abnormalities were comparable between MD ears and control ears. As for VA-related indices, the CT-VA visibility was lower in MD ears than in control ears (p = 0.004). The distribution of CT-VA morphology was significantly different between MD and control ears (p = 0.013), with a higher proportion of obliterated-shaped type in MD ears (22.1%) than in control ears (6.6%).
UNASSIGNED: Compared with JB abnormalities, the anatomical variations of VA are more likely to be an anatomically predisposing factor for MD.
摘要：
■内耳的解剖变异可能有助于梅尼埃病（MD）的发展，这是一种复杂的内耳疾病，在组织病理学上表现为特发性内淋巴积液（ELH）。前庭水管（VA）和颈静脉球（JB）的异常被认为是诱发因素。然而，很少有研究调查了这些患者中JB异常与VA变异之间的相关性及其临床意义。在这项回顾性研究中,我们调查了明确MD患者VA和JB放射学异常发生率的差异。
■根据高分辨率CT（HRCT）评估了103例MD患者（单侧93例，双侧10例）的JB和VA的解剖变异。JB相关指标包括JB前后径和中外侧径，JB高度,关于Manjila分类系统的JB类型，和JB憩室(JBD)的发生率，JB相关内耳开裂（JBID），和内耳相邻JB(IAJB)。VA相关指标包括CT-VA能见度，CT-VA形态学(漏斗,管状,丝状体,空心,和消隐型)，和VA周围的气动。比较了MD耳和对照耳之间的放射学指标。
■MD耳和对照耳之间的放射学JB异常相当。至于与VA相关的指数，MD耳的CT-VA能见度低于对照耳(p=0.004)。MD和对照耳的CT-VA形态分布有显著差异(p=0.013),MD耳的消隐型比例（22.1％）高于对照耳（6.6％）。
■与JB异常相比，VA的解剖学变异更可能是MD的解剖学诱发因素。
■根据高分辨率CT（HRCT）评估了103例MD患者（单侧93例，双侧10例）的JB和VA的解剖变异。JB相关指标包括JB前后径和中外侧径，JB高度,关于Manjila分类系统的JB类型，和JB憩室(JBD)的发生率，JB相关内耳开裂（JBID），和内耳相邻JB(IAJB)。VA相关指标包括CT-VA能见度，CT-VA形态学(漏斗,管状,丝状体,空心,和消隐型)，和VA周围的气动。比较了MD耳和对照耳之间的放射学指标。
■MD耳和对照耳之间的放射学JB异常相当。至于与VA相关的指数，MD耳的CT-VA能见度低于对照耳(p=0.004)。MD和对照耳的CT-VA形态分布有显著差异(p=0.013),MD耳的消隐型比例（22.1％）高于对照耳（6.6％）。
■与JB异常相比，VA的解剖学变异更可能是MD的解剖学诱发因素。
