PDF(Pubmed)
Abstract：
The Wnt/β-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/β-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.
摘要：
Wnt/β-catenin信号通路是参与多种生物学过程以及癌症发生发展的生长控制通路。结直肠癌(CRC)是世界上最常见的恶性肿瘤之一。在几乎所有CRC中都观察到Wnt信号的过度激活，并且在癌症相关过程中发挥关键作用，例如癌症干细胞（CSC）传播。血管生成,上皮-间质转化（EMT），化学抗性，和转移。本文就Wnt/β-catenin信号通路如何参与CRC的发生发展及相关治疗方法作一综述。
