Abstract：
In this randomized, double-blind, placebo-controlled study, we investigated the effects of collagen peptides (CP) containing high concentrations of prolyl-hydroxyproline and hydroxyprolyl-glycine on advanced glycation end products (AGEs) levels in the skin and subcutaneous blood vessel walls. A total of 31 individuals aged 47-87 years were randomly assigned to receive either 5 g/day of fish-derived CP or a placebo for 12 weeks. Body and blood compositions and AGEs levels were measured at the beginning and end of the study. No adverse events were observed, and both groups\' blood and body compositions did not change significantly. However, the CP group had significantly lower AGEs levels and a slightly lower insulin resistance index (homeostasis model assessment ratio [HOMA-R]) than the placebo group. In addition, the percentage changes in AGEs and HOMA-R levels were positively and strongly correlated in both groups. These findings suggest that fish-derived CP may be effective in reducing AGEs levels and improving insulin resistance.
摘要：
在这个随机的，双盲,安慰剂对照研究，我们研究了含有高浓度脯氨酸-羟脯氨酸和羟脯氨酸-甘氨酸的胶原肽(CP)对皮肤和皮下血管壁中晚期糖基化终产物(AGEs)水平的影响.31名年龄在47-87岁的个体被随机分配接受5g/天的鱼源CP或安慰剂12周。在研究开始和结束时测量身体和血液成分以及AGEs水平。没有观察到不良事件，两组的血液和身体成分没有明显变化。然而,CP组的AGEs水平显著低于安慰剂组,胰岛素抵抗指数(HOMA-R)略低于安慰剂组.此外,在两组中,AGEs和HOMA-R水平的%变化呈正相关.这些发现表明鱼源性CP可能有效降低AGEs水平并改善胰岛素抵抗。
