PDF(Pubmed)
Abstract：
The recent multi-country outbreak of Mpox (Monkeypox disease) constituted a public health emergency. Although animal-to-human transmission is known to be the primary way of transmission, an increasing number of cases transmitted by person-to-person contact have been reported. During the recent Mpox outbreak sexual or intimate contact has been considered the most important way of transmission. However, other routes of transmission must not be ignored. The knowledge of how the Monkeypox Virus (MPXV) spreads is crucial to implement adequate measures to contain the spread of the disease. Therefore, this systematic review aimed to collect scientific data published concerning other implicated sources of infection beyond sexual interaction, such as the involvement of respiratory particles, contact with contaminated surfaces and skin-to-skin contact. The current study was performed using the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Publications analyzing contacts of Mpox index cases and their outcome after contact were included. A total of 7319 person-to-person contacts were surveyed and 273 of them became positive cases. Positive secondary transmission of MPXV was verified after contact with people cohabiting in the same household, with family members, with healthcare workers, or within healthcare facilities, and sexual contact or contact with contaminated surfaces. Using the same cup, sharing the same dishes, and sleeping in the same room or bed were also positively associated with transmission. Five studies showed no evidence of transmission despite contact with surfaces, skin-to-skin contact, or through airway particles within healthcare facilities where containment measures were taken. These records support the case for person-to-person transmission and suggest that other types of contact beyond sexual contact pose a significant risk of acquiring the infection. Further investigation is crucial to elucidate MPXV transmission dynamics, and to implement adequate measures to contain the spread of the infection.
摘要：
近期多国爆发的猴痘(Monkeypoxdisease)已构成突发公共卫生事件。尽管已知动物到人的传播是主要的传播方式，据报告，通过人与人接触传播的病例越来越多。在最近的水痘爆发期间，性或亲密接触被认为是最重要的传播方式。然而,其他传播途径不可忽视。猴痘病毒（MPXV）如何传播的知识对于实施适当的措施来遏制疾病的传播至关重要。因此,这项系统评价旨在收集发表的关于性互动以外的其他牵连感染源的科学数据，比如呼吸微粒的参与，接触污染表面和皮肤与皮肤接触。本研究采用系统评价和荟萃分析（PRISMA）的首选报告项目指南进行。包括分析Mpox指数病例的接触及其接触后结果的出版物。共调查了7319人与人之间的接触，其中273人成为阳性病例。在与同居的人接触后，验证了MPXV的阳性二次传播，和家人在一起,与医护人员一起，或在医疗保健设施内，以及性接触或与污染表面接触。用同一个杯子,分享同样的菜肴，在同一房间或床上睡觉也与传播呈正相关。五项研究表明，尽管与表面接触，但没有传播的证据，皮肤与皮肤的接触,或通过采取控制措施的医疗机构内的气道颗粒。这些记录支持人与人之间传播的情况，并表明性接触以外的其他类型的接触会带来感染的巨大风险。进一步的研究对于阐明MPXV传输动力学至关重要，并采取适当措施遏制感染的传播。
