PDF(Pubmed)
Abstract：
COVID-19 is a major global health threat, with millions of confirmed cases and deaths worldwide. Containment and mitigation strategies, including vaccination, have been implemented to reduce transmission and protect the population. We conducted two systematic reviews to collect nonrandomized studies investigating the effects of vaccination on COVID-19-related complications and deaths in the Italian population. We considered studies conducted in Italian settings and written in English that contained data on the effects of vaccination on COVID-19-related mortality and complications. We excluded studies that pertained to the pediatric population. In total, we included 10 unique studies in our two systematic reviews. The results showed that fully vaccinated individuals had a lower risk of death, severe symptoms, and hospitalization compared to unvaccinated individuals. The review also looked at the impact of vaccination on post-COVID-19 syndrome, the effectiveness of booster doses in older individuals, and nationwide adverse events. Our work highlights the crucial role that vaccination campaigns have played in reducing the burden of COVID-19 disease in the Italian adult population, positively impacting the pandemic trajectory in Italy.
摘要：
COVID-19是一个主要的全球健康威胁，全球数百万例确诊病例和死亡病例。遏制和缓解策略，包括疫苗接种，已实施以减少传播和保护人口。我们进行了两项系统评价，以收集非随机研究，调查疫苗接种对意大利人群COVID-19相关并发症和死亡的影响。我们考虑了在意大利环境中进行的研究，这些研究以英语编写，其中包含疫苗接种对COVID-19相关死亡率和并发症影响的数据。我们排除了与儿科人群有关的研究。总的来说,我们在两项系统综述中纳入了10项独特研究.结果显示，完全接种疫苗的个体死亡风险较低，严重症状,与未接种疫苗的人相比，住院治疗。审查还研究了疫苗接种对COVID-19后综合征的影响，加强剂量对老年人的有效性，和全国性的不良事件。我们的工作突出了疫苗接种运动在减轻意大利成年人群COVID-19疾病负担方面发挥的关键作用，对意大利的大流行轨迹产生了积极影响。
