PDF(Pubmed)
Abstract：
BACKGROUND: Fetal magnetocardiography (fMCG) is considered the best technique for diagnosis of fetal arrhythmia. It is superior to more widely used methods such as fetal, fetal electrocardiography, and cardiotocography for evaluation of fetal rhythm. The combination of fMCG and fetal echocardiography can provide a more comprehensive evaluation of fetal cardiac rhythm and function than is currently possible. In this study, we demonstrate a practical fMCG system based on optically pumped magnetometers (OPMs).
METHODS: Seven pregnant women with uncomplicated pregnancies underwent fMCG at 26-36 weeks\' gestation. The recordings were made using an OPM-based fMCG system and a person-sized magnetic shield. The shield is much smaller than a shielded room and provides easy access with a large opening that allows the pregnant woman to lie comfortably in a prone position.
RESULTS: The data show no significant loss of quality compared to data acquired in a shielded room. Measurements of standard cardiac time intervals yielded the following results: PR = 104 ± 6 ms, QRS = 52.6 ± 1.5 ms, and QTc = 387 ± 19 ms. These results are compatible with those from prior studies performed using superconducting quantum interference device (SQUID) fMCG systems.
CONCLUSIONS: To our knowledge, this is the first European fMCG device with OPM technology commissioned for basic research in a pediatric cardiology unit. We demonstrated a patient-friendly, comfortable, and open fMCG system. The data yielded consistent cardiac intervals, measured from time-averaged waveforms, compatible with published SQUID and OPM data. This is an important step toward making the method widely accessible.
METHODS: Seven pregnant women with uncomplicated pregnancies underwent fMCG at 26-36 weeks\' gestation. The recordings were made using an OPM-based fMCG system and a person-sized magnetic shield. The shield is much smaller than a shielded room and provides easy access with a large opening that allows the pregnant woman to lie comfortably in a prone position.
RESULTS: The data show no significant loss of quality compared to data acquired in a shielded room. Measurements of standard cardiac time intervals yielded the following results: PR = 104 ± 6 ms, QRS = 52.6 ± 1.5 ms, and QTc = 387 ± 19 ms. These results are compatible with those from prior studies performed using superconducting quantum interference device (SQUID) fMCG systems.
CONCLUSIONS: To our knowledge, this is the first European fMCG device with OPM technology commissioned for basic research in a pediatric cardiology unit. We demonstrated a patient-friendly, comfortable, and open fMCG system. The data yielded consistent cardiac intervals, measured from time-averaged waveforms, compatible with published SQUID and OPM data. This is an important step toward making the method widely accessible.
摘要：
背景：胎儿心磁图（fMCG）被认为是诊断胎儿心律失常的最佳技术。它优于更广泛使用的方法，如胎儿，胎儿心电图,和用于评估胎儿节律的心脏造影。fMCG和胎儿超声心动图的组合可以提供比目前更全面的胎儿心律和功能评估。在这项研究中,我们展示了一种基于光泵浦磁力计（OPM）的实用快速消费品系统。
方法：7名无并发症妊娠的孕妇在妊娠26-36周时接受了fMCG。使用基于OPM的fMCG系统和人大小的磁屏蔽进行记录。防护罩比屏蔽室小得多，并提供了一个大开口，使孕妇可以舒适地躺在俯卧位的方便。
结果：数据显示，与在屏蔽室中获取的数据相比，质量没有显着损失。标准心脏时间间隔的测量得出以下结果：PR=104±6ms，QRS=52.6±1.5ms，QTc=387±19ms。这些结果与使用超导量子干涉器件（SQUID）fMCG系统进行的先前研究的结果兼容。
结论：据我们所知，这是欧洲首个具有OPM技术的fMCG设备，委托儿科心脏病学部门进行基础研究。我们展示了一个对病人友好的，舒适,和开放的快速消费品系统。数据产生了一致的心脏间隔，从时间平均波形测量，与发布的SQUID和OPM数据兼容。这是使该方法广泛使用的重要步骤。
方法：7名无并发症妊娠的孕妇在妊娠26-36周时接受了fMCG。使用基于OPM的fMCG系统和人大小的磁屏蔽进行记录。防护罩比屏蔽室小得多，并提供了一个大开口，使孕妇可以舒适地躺在俯卧位的方便。
结果：数据显示，与在屏蔽室中获取的数据相比，质量没有显着损失。标准心脏时间间隔的测量得出以下结果：PR=104±6ms，QRS=52.6±1.5ms，QTc=387±19ms。这些结果与使用超导量子干涉器件（SQUID）fMCG系统进行的先前研究的结果兼容。
结论：据我们所知，这是欧洲首个具有OPM技术的fMCG设备，委托儿科心脏病学部门进行基础研究。我们展示了一个对病人友好的，舒适,和开放的快速消费品系统。数据产生了一致的心脏间隔，从时间平均波形测量，与发布的SQUID和OPM数据兼容。这是使该方法广泛使用的重要步骤。
