PDF(Pubmed)
Abstract：
The activation of G-protein-coupled receptors (GPCRs) triggers a series of protein-protein interaction events that subsequently induce a chain of reactions, including alteration of receptor structures, phosphorylation, recruitment of associated proteins, protein trafficking and gene expression. Multiple GPCR signaling transduction pathways are evident - two well-studied pathways are the GPCR-mediated G-protein and β-arrestin pathways. Recently, ligand-induced interactions between GPCRs and 14-3-3 proteins have been demonstrated. This linking of GPCRs to 14-3-3 protein signal hubs opens up a whole new realm of signal transduction possibilities. 14-3-3 proteins play a key part in GPCR trafficking and signal transduction. GPCR-mediated 14-3-3 protein signaling can be harnessed for the study of GPCR function and therapeutics.
摘要：
G蛋白偶联受体（GPCRs）的激活引发一系列蛋白质-蛋白质相互作用事件，随后诱导一系列反应，包括受体结构的改变，磷酸化,相关蛋白质的募集，蛋白质运输和基因表达。多种GPCR信号转导途径是明显的-两种充分研究的途径是GPCR介导的G蛋白和β-抑制蛋白途径。最近,配体诱导的GPCRs和14-3-3蛋白之间的相互作用已经被证明。GPCR与14-3-3蛋白质信号中心的这种连接开辟了信号转导可能性的全新领域。14-3-3蛋白在GPCR运输和信号转导中起关键作用。GPCR介导的14-3-3蛋白信号可以用于GPCR功能和治疗的研究。Teaser：14-3-3蛋白参与GPCRs的动态和多方面的信号转导。它们在大脑中的突出表达和在神经元可塑性中的关键作用强调了靶向GPCR和14-3-3相互作用用于CNS药物开发的潜力。
