%0 Journal Article
%T Modulating GPCR and 14-3-3 protein interactions: Prospects for CNS drug discovery.
%A Kongsamut S
%A Eishingdrelo H
%J Drug Discov Today
%V 28
%N 8
%D 2023 08 24
%M 37236523
%F 8.369
%R 10.1016/j.drudis.2023.103641
%X The activation of G-protein-coupled receptors (GPCRs) triggers a series of protein-protein interaction events that subsequently induce a chain of reactions, including alteration of receptor structures, phosphorylation, recruitment of associated proteins, protein trafficking and gene expression. Multiple GPCR signaling transduction pathways are evident - two well-studied pathways are the GPCR-mediated G-protein and β-arrestin pathways. Recently, ligand-induced interactions between GPCRs and 14-3-3 proteins have been demonstrated. This linking of GPCRs to 14-3-3 protein signal hubs opens up a whole new realm of signal transduction possibilities. 14-3-3 proteins play a key part in GPCR trafficking and signal transduction. GPCR-mediated 14-3-3 protein signaling can be harnessed for the study of GPCR function and therapeutics.