PDF(Pubmed)
Abstract：
Regulating calcium ion (Ca2+) channels to improve the cell cycle and metabolism is a promising technology, ensuring increased cell growth, differentiation, and/or productivity. In this regard, the composition and structure of Ca2+ channels play a vital role in controlling the gating states. In this review, Saccharomyces cerevisiae, as a model eukaryotic organism and an essential industrial microorganism, was used to discuss the effect of its type, composition, structure, and gating mechanism on the activity of Ca2+ channels. Furthermore, the advances in the application of Ca2+ channels in pharmacology, tissue engineering, and biochemical engineering are summarized, with a special focus on exploring the receptor site of Ca2+ channels for new drug design strategies and different therapeutic uses, targeting Ca2+ channels to produce functional replacement tissues, creating favorable conditions for tissue regeneration, and regulating Ca2+ channels to enhance biotransformation efficiency.
摘要：
调节钙离子(Ca2+)通道改善细胞周期和新陈代谢是一项很有前途的技术,确保细胞生长增加，分化,和/或生产力。在这方面,Ca2+通道的组成和结构在控制门控态中起着至关重要的作用。在这次审查中,酿酒酵母，作为模型真核生物和重要的工业微生物，被用来讨论其类型的影响，composition,结构,以及对Ca2+通道活性的门控机制。此外，Ca2+通道在药理学中的应用进展,组织工程,和生化工程进行了总结，特别关注探索Ca2+通道的受体位点，用于新药设计策略和不同的治疗用途，靶向Ca2+通道以产生功能性替代组织，为组织再生创造有利条件，并调节Ca2+通道以提高生物转化效率。
