{Reference Type}: Journal Article
{Title}: Calcium Ion Channels in Saccharomyces cerevisiae.
{Author}: Dong XY;
{Journal}: J Fungi (Basel)
{Volume}: 9
{Issue}: 5
{Year}: 2023 Apr 28
{Factor}: 5.724
{DOI}: 10.3390/jof9050524
{Abstract}: Regulating calcium ion (Ca2+) channels to improve the cell cycle and metabolism is a promising technology, ensuring increased cell growth, differentiation, and/or productivity. In this regard, the composition and structure of Ca2+ channels play a vital role in controlling the gating states. In this review, Saccharomyces cerevisiae, as a model eukaryotic organism and an essential industrial microorganism, was used to discuss the effect of its type, composition, structure, and gating mechanism on the activity of Ca2+ channels. Furthermore, the advances in the application of Ca2+ channels in pharmacology, tissue engineering, and biochemical engineering are summarized, with a special focus on exploring the receptor site of Ca2+ channels for new drug design strategies and different therapeutic uses, targeting Ca2+ channels to produce functional replacement tissues, creating favorable conditions for tissue regeneration, and regulating Ca2+ channels to enhance biotransformation efficiency.