PDF(Pubmed)
Abstract：
Neuropathic pain is a complex and debilitating condition that affects millions of people worldwide. While several treatment options are available, they often have limited efficacy and are associated with adverse effects. In recent years, gels have emerged as a promising option for the treatment of neuropathic pain. Inclusion of various nanocarriers, such as cubosomes and niosomes, into gels results in pharmaceutical forms with higher drug stability and increased drug penetration into tissues compared to products currently marketed for the treatment of neuropathic pain. Furthermore, these compounds usually provide sustained drug release and are biocompatible and biodegradable, which makes them a safe option for drug delivery. The purpose of this narrative review was to provide a comprehensive analysis of the current state of the field and identify potential directions for future research in the development of effective and safe gels for the treatment of neuropathic pain, ultimately improving the quality of life for patients suffering from neuropathic pain.
摘要：
神经性疼痛是一种复杂且使人衰弱的疾病，影响着全世界数百万人。虽然有几种治疗选择，它们通常疗效有限，并伴有不良反应。近年来,凝胶已成为治疗神经性疼痛的有希望的选择。包含各种纳米载体，如立方体和niosomes，与目前市售的用于治疗神经性疼痛的产品相比,在凝胶中形成的药物形式产生具有更高的药物稳定性和增加的药物向组织中的渗透。此外，这些化合物通常提供持续的药物释放，并且具有生物相容性和生物可降解性，这使得它们成为药物输送的安全选择。这篇叙述性综述的目的是对该领域的现状进行全面分析，并确定未来研究开发有效和安全的治疗神经性疼痛的凝胶的潜在方向。最终改善神经性疼痛患者的生活质量。
