PDF(Pubmed)
Abstract：
Usutu virus (USUV) is an arthropod-borne flavivirus emerged in Africa in 1950s and in Eruope in 1990s causing a massive number of birds\' deaths. The role of USUV as human pathogen has been only recently hypothesized and cases of USUV infection in humans remain limited and often related to immunocompromised subjects. Herein, we report a case of USUV meningoencephalitis infection in an immunocompromised patient with no history of previous flavivirus infection. The infection due to USUV evolved rapidly since hospital admission thus resulting fatal in few days after symptoms onset and, although not proven, a suspected bacteria co-infection has been hypothesized. Based on these findings, we suggested that when USUV meningoencephalitis is suspected in countries endemic, careful attention should be applied to neurological syndromes during summer months especially among immunocompromised patients.
摘要：
Usutu病毒（USUV）是一种节肢动物传播的黄病毒，于1950年代在非洲和1990年代在Eruope中出现，导致大量鸟类死亡。USUV作为人类病原体的作用最近才被假设,并且人类中USUV感染的病例仍然有限,并且通常与免疫受损的受试者有关。在这里，我们报告了1例UUV脑膜脑炎感染病例,该病例是1例免疫功能低下患者,既往无黄病毒感染史.由USUV引起的感染自入院后迅速发展，因此在症状发作后几天内致命，虽然没有证明,假设有疑似细菌共感染。基于这些发现,我们建议，当USUV脑膜脑炎在流行国家被怀疑时，在夏季，尤其是在免疫功能低下的患者中，应特别注意神经系统综合征。
