PDF(Pubmed)
Abstract：
Brain metastases (BM) in patients with thyroid cancer (TC) are rare with an incidence of 1% for papillary and follicular, 3% for medullary and up to 10% for anaplastic TC (PTC, FTC, MTC and ATC). Little is known about the characteristics and management of BM from TC. Thus, we retrospectively analyzed patients with histologically verified TC and radiologically verified BM identified from the Vienna Brain Metastasis Registry. A total of 20/6074 patients included in the database since 1986 had BM from TC and 13/20 were female. Ten patients had FTC, 8 PTC, one MTC and one ATC. The median age at diagnosis of BM was 68 years. All but one had symptomatic BM and 13/20 patients had a singular BM. Synchronous BM at primary diagnosis were found in 6 patients, while the median time to BM diagnosis was 13 years for PTC (range 1.9-24), 4 years for FTC (range 2.1-41) and 22 years for the MTC patient. The overall survival from diagnosis of BM was 13 months for PTC (range 1.8-57), 26 months for FTC (range 3.9-188), 12 years for the MTC and 3 months for the ATC patient. In conclusion, development of BM from TC is exceedingly rare and the most common presentation is a symptomatic single lesion. While BM generally constitute a poor prognostic factor, individual patients experience long-term survival following local therapy.
摘要：
甲状腺癌（TC）患者的脑转移（BM）很少见，乳头状和滤泡性的发生率为1％，髓质为3%，间变性TC为10%(PTC，联邦贸易委员会,MTC和ATC）。关于TC的BM的特征和管理知之甚少。因此，我们回顾性分析了在维也纳脑转移登记处发现的经组织学证实的TC和经放射学证实的BM患者.自1986年以来，数据库中总共有20/6074名患者患有来自TC的BM，而13/20为女性。十个病人有FTC,8PTC,一个MTC和一个ATC。诊断BM的中位年龄为68岁。除一名患者外，所有患者均有症状性BM，13/20患者有单一BM。在6例患者中发现了初步诊断的同步BM，虽然PTC诊断BM的中位时间为13年（范围1.9-24），FTC为4年（范围2.1-41），MTC患者为22年。PTC诊断为BM的总生存期为13个月（范围1.8-57），FTC26个月（范围3.9-188），MTC为12年，ATC患者为3个月。总之,由TC引起的BM极为罕见，最常见的表现是有症状的单个病变。虽然BM通常构成不良预后因素，个别患者在局部治疗后经历长期生存.
