PDF(Pubmed)
Abstract：
UNASSIGNED: To evaluate the clinical characteristics of simultaneous bilateral sudden sensorineural hearing loss (Si-BSSNHL) as well as its prognostic factors.
UNASSIGNED: Patients with Si-BSSNHL who were admitted to the Department of Otology Medicine between December 2018 and December 2021 were enrolled in the case group. Propensity score matching (PSM) for sex and age was used to select the control group, which included people who had unilateral sudden sensorineural hearing loss (USSNHL) during the same time period. Hearing recovery, audiological examinations, vestibular function assessments, laboratory tests, and demographic and clinical manifestations were analyzed for intergroup comparisons. Binary logistic regressions were used for both univariate and multivariate analyses of Si-BSSNHL prognostic factors.
UNASSIGNED: Before PSM, the Si-BSSNHL and USSNHL groups differed significantly (p < 0.05) in terms of time from onset to treatment, initial pure-tone average (PTA), final PTA, hearing gain, audiogram curve type, proportion of tinnitus, high-density lipoprotein level, homocysteine level, and effective rate. After PSM, significant differences were also observed in time from onset to treatment, initial PTA, final PTA, hearing gain, total and indirect bilirubin levels, homocysteine level, and effective rate between the two groups (p < 0.05). There was a significant difference in the classification of therapeutic effects between the two groups (p < 0.001). For prognostic analysis, the audiogram curve type was significantly different between the effective group and the ineffective groups of Si-BSSNHL (p = 0.01), in which the sloping type was an independent risk factor for the prognosis of the right ear in Si-SSNHL (95% confidence interval, 0.006-0.549, p = 0.013).
UNASSIGNED: Patients with Si-BSSNHL had mild deafness, elevated total and indirect bilirubin and homocysteine levels, and poorer prognosis than those with USSNHL. Audiogram curve type was linked to the therapeutic effect of Si-BSSNHL, and the sloping type was an independent risk factor for a poor prognosis in the right ear of Si-SSNHL.
UNASSIGNED: Patients with Si-BSSNHL who were admitted to the Department of Otology Medicine between December 2018 and December 2021 were enrolled in the case group. Propensity score matching (PSM) for sex and age was used to select the control group, which included people who had unilateral sudden sensorineural hearing loss (USSNHL) during the same time period. Hearing recovery, audiological examinations, vestibular function assessments, laboratory tests, and demographic and clinical manifestations were analyzed for intergroup comparisons. Binary logistic regressions were used for both univariate and multivariate analyses of Si-BSSNHL prognostic factors.
UNASSIGNED: Before PSM, the Si-BSSNHL and USSNHL groups differed significantly (p < 0.05) in terms of time from onset to treatment, initial pure-tone average (PTA), final PTA, hearing gain, audiogram curve type, proportion of tinnitus, high-density lipoprotein level, homocysteine level, and effective rate. After PSM, significant differences were also observed in time from onset to treatment, initial PTA, final PTA, hearing gain, total and indirect bilirubin levels, homocysteine level, and effective rate between the two groups (p < 0.05). There was a significant difference in the classification of therapeutic effects between the two groups (p < 0.001). For prognostic analysis, the audiogram curve type was significantly different between the effective group and the ineffective groups of Si-BSSNHL (p = 0.01), in which the sloping type was an independent risk factor for the prognosis of the right ear in Si-SSNHL (95% confidence interval, 0.006-0.549, p = 0.013).
UNASSIGNED: Patients with Si-BSSNHL had mild deafness, elevated total and indirect bilirubin and homocysteine levels, and poorer prognosis than those with USSNHL. Audiogram curve type was linked to the therapeutic effect of Si-BSSNHL, and the sloping type was an independent risk factor for a poor prognosis in the right ear of Si-SSNHL.
摘要：
■评估同期双侧突发性感音神经性耳聋（Si-BSSNHL）的临床特征及其预后因素。
■2018年12月至2021年12月间入住耳科的Si-BSSNHL患者纳入病例组。采用性别、年龄倾向评分匹配(PSM)选择对照组,其中包括在同一时间段内发生单侧突发性感觉神经性听力损失（USSNHL）的患者。听力恢复,听力学检查,前庭功能评估，实验室测试,并对人口统计学和临床表现进行组间比较分析。二元逻辑回归用于Si-BSSNHL预后因素的单变量和多变量分析。
■PSM之前，Si-BSSNHL和USSNHL组在从发病到治疗的时间方面存在显着差异（p<0.05），初始纯音平均(PTA)，最终PTA,听力增益,听力图曲线类型,耳鸣比例，高密度脂蛋白水平，同型半胱氨酸水平,和有效率。PSM之后,从发病到治疗的时间也有显著差异，初始PTA,最终PTA,听力增益,总胆红素和间接胆红素水平，同型半胱氨酸水平,两组有效率比较(p<0.05)。两组间的治疗效果分类有显著差异(p<0.001)。对于预后分析，Si-BSSNHL有效组与无效组之间的听力图曲线类型存在显着差异（p=0.01），其中倾斜类型是Si-SSNHL右耳预后的独立危险因素（95％置信区间，0.006-0.549，p=0.013）。
■Si-BSSNHL患者有轻度耳聋,总胆红素和间接胆红素和同型半胱氨酸水平升高，与USSNHL患者相比，预后较差。听力图曲线类型与Si-BSSNHL的治疗效果有关,倾斜型是Si-SSNHL右耳预后不良的独立危险因素。
■2018年12月至2021年12月间入住耳科的Si-BSSNHL患者纳入病例组。采用性别、年龄倾向评分匹配(PSM)选择对照组,其中包括在同一时间段内发生单侧突发性感觉神经性听力损失（USSNHL）的患者。听力恢复,听力学检查,前庭功能评估，实验室测试,并对人口统计学和临床表现进行组间比较分析。二元逻辑回归用于Si-BSSNHL预后因素的单变量和多变量分析。
■PSM之前，Si-BSSNHL和USSNHL组在从发病到治疗的时间方面存在显着差异（p<0.05），初始纯音平均(PTA)，最终PTA,听力增益,听力图曲线类型,耳鸣比例，高密度脂蛋白水平，同型半胱氨酸水平,和有效率。PSM之后,从发病到治疗的时间也有显著差异，初始PTA,最终PTA,听力增益,总胆红素和间接胆红素水平，同型半胱氨酸水平,两组有效率比较(p<0.05)。两组间的治疗效果分类有显著差异(p<0.001)。对于预后分析，Si-BSSNHL有效组与无效组之间的听力图曲线类型存在显着差异（p=0.01），其中倾斜类型是Si-SSNHL右耳预后的独立危险因素（95％置信区间，0.006-0.549，p=0.013）。
■Si-BSSNHL患者有轻度耳聋,总胆红素和间接胆红素和同型半胱氨酸水平升高，与USSNHL患者相比，预后较差。听力图曲线类型与Si-BSSNHL的治疗效果有关,倾斜型是Si-SSNHL右耳预后不良的独立危险因素。
