PDF(Pubmed)
Abstract：
It has been shown that people with type 2 diabetes have a higher risk of synovitis and tenosynovitis, but previous studies were mainly observational, which may be biased and does not allow for a cause-and-effect relationship. Therefore, we conducted a two-sample Mendelian randomization (MR) study to investigate the causal relationship.
We obtained data on \"type 2 diabetes\" and \"synovitis, tenosynovitis\" from published large-scale genome-wide association studies (GWAS). The data were obtained from the FinnGen consortium and UK Biobank, both from European population samples. We used three methods to perform a two-sample MR analysis and also performed sensitivity analysis.
The results of all three MR methods we used for the analysis illustrated that T2DM increases the risk factor for the development of synovitis and tenosynovitis. Specifically, for the IVW method as the primary analysis outcome, OR = 1.0015 (95% CI, 1.0005 to 1.0026), P = 0.0047; for the MR Egger method as the supplementary analysis outcome, OR = 1.0032 (95% CI, 1.0007 to 1.0056), P = 0.0161; for the weighted median method, OR = 1.0022 (95% CI, 1.0008 to 1.0037), p = 0.0018. In addition, the results of our sensitivity analysis suggest the absence of heterogeneity and pleiotropy in our MR analysis.
In conclusion, the results of our MR analysis suggest that T2DM is an independent risk factor for increased synovitis and tenosynovitis.
We obtained data on \"type 2 diabetes\" and \"synovitis, tenosynovitis\" from published large-scale genome-wide association studies (GWAS). The data were obtained from the FinnGen consortium and UK Biobank, both from European population samples. We used three methods to perform a two-sample MR analysis and also performed sensitivity analysis.
The results of all three MR methods we used for the analysis illustrated that T2DM increases the risk factor for the development of synovitis and tenosynovitis. Specifically, for the IVW method as the primary analysis outcome, OR = 1.0015 (95% CI, 1.0005 to 1.0026), P = 0.0047; for the MR Egger method as the supplementary analysis outcome, OR = 1.0032 (95% CI, 1.0007 to 1.0056), P = 0.0161; for the weighted median method, OR = 1.0022 (95% CI, 1.0008 to 1.0037), p = 0.0018. In addition, the results of our sensitivity analysis suggest the absence of heterogeneity and pleiotropy in our MR analysis.
In conclusion, the results of our MR analysis suggest that T2DM is an independent risk factor for increased synovitis and tenosynovitis.
摘要：
■已经表明，患有2型糖尿病的人患滑膜炎和腱鞘炎的风险更高，但是以前的研究主要是观察性的，这可能是有偏见的，不允许有因果关系。因此,我们进行了双样本孟德尔随机化(MR)研究以调查因果关系.
■我们获得了关于“2型糖尿病”和“滑膜炎”的数据，来自已发表的大规模全基因组关联研究(GWAS)的腱鞘炎。数据来自FinnGen财团和英国生物银行，两者都来自欧洲人口样本。我们使用三种方法进行了双样本MR分析，并进行了敏感性分析。
■我们用于分析的所有三种MR方法的结果表明，T2DM增加了滑膜炎和腱鞘炎发展的危险因素。具体来说,对于IVW方法作为主要分析结果，OR=1.0015（95%CI，1.0005至1.0026），P=0.0047；对于作为补充分析结果的MREgger方法，OR=1.0032（95%CI，1.0007至1.0056），P=0.0161；对于加权中位数法，OR=1.0022（95%CI，1.0008至1.0037），p=0.0018。此外,我们的敏感性分析结果表明,我们的MR分析中不存在异质性和多效性.
■总而言之，我们的MR分析结果表明,T2DM是滑膜炎和腱鞘炎增加的独立危险因素.
■我们获得了关于“2型糖尿病”和“滑膜炎”的数据，来自已发表的大规模全基因组关联研究(GWAS)的腱鞘炎。数据来自FinnGen财团和英国生物银行，两者都来自欧洲人口样本。我们使用三种方法进行了双样本MR分析，并进行了敏感性分析。
■我们用于分析的所有三种MR方法的结果表明，T2DM增加了滑膜炎和腱鞘炎发展的危险因素。具体来说,对于IVW方法作为主要分析结果，OR=1.0015（95%CI，1.0005至1.0026），P=0.0047；对于作为补充分析结果的MREgger方法，OR=1.0032（95%CI，1.0007至1.0056），P=0.0161；对于加权中位数法，OR=1.0022（95%CI，1.0008至1.0037），p=0.0018。此外,我们的敏感性分析结果表明,我们的MR分析中不存在异质性和多效性.
■总而言之，我们的MR分析结果表明,T2DM是滑膜炎和腱鞘炎增加的独立危险因素.
