Abstract：
A list of drugs that can induce takotsubo cardiomyopathy (TCM) was published in 2011 and 2016. The aim of the present review was to update this list.
Similar to the 2011 and 2016 reviews, from April 2015 to May 2022 case reports of druginduced TCM were identified by a comprehensive search in Medline/PubMed database. The search terms were: takotsubo cardiomyopathy, tako-tsubo cardiomyopathy, stress cardiomyopathy, transientleft- ventricular ballooning syndrome, apical ballooning syndrome, ampulla cardiomyopathy OR broken heart syndrome; together with \"iatrogenic\", \"induced by\" OR \"drug-induced\". Registers published in English or Spanish, in humans, and with full texts were retrieved. Articles that recognized any drug associated with the development of TCM were selected.
Overall, 184 manuscripts were identified by the search. A total of 39 articles were included after an exhaustive revision. Eighteen drugs as possible triggers of TCM were identified in the current update. Of them, 3 (16.7%) have been previously identified, and 15 (83.3%) are different from the previous reports. Thus, the list of drugs as possible triggers of TCM updated in 2022 includes 72 drugs.
There are new case reports that link drugs with the development of TCM. The current list is principally made up of drugs that generate sympathetic overstimulation. However, some of the listed drugs do not have a clear link with sympathetic activation.
Similar to the 2011 and 2016 reviews, from April 2015 to May 2022 case reports of druginduced TCM were identified by a comprehensive search in Medline/PubMed database. The search terms were: takotsubo cardiomyopathy, tako-tsubo cardiomyopathy, stress cardiomyopathy, transientleft- ventricular ballooning syndrome, apical ballooning syndrome, ampulla cardiomyopathy OR broken heart syndrome; together with \"iatrogenic\", \"induced by\" OR \"drug-induced\". Registers published in English or Spanish, in humans, and with full texts were retrieved. Articles that recognized any drug associated with the development of TCM were selected.
Overall, 184 manuscripts were identified by the search. A total of 39 articles were included after an exhaustive revision. Eighteen drugs as possible triggers of TCM were identified in the current update. Of them, 3 (16.7%) have been previously identified, and 15 (83.3%) are different from the previous reports. Thus, the list of drugs as possible triggers of TCM updated in 2022 includes 72 drugs.
There are new case reports that link drugs with the development of TCM. The current list is principally made up of drugs that generate sympathetic overstimulation. However, some of the listed drugs do not have a clear link with sympathetic activation.
摘要：
背景：2011年和2016年发布了可诱发takotsubo心肌病（TCM）的药物清单。本次审查的目的是更新这一清单。
方法：类似于2011年和2016年的评论，从2015年4月至2022年5月,通过在Medline/PubMed数据库中进行全面搜索,确定了药物诱导的中医病例报告.搜索词是:塔科特subo心肌病，tako-tsubo心肌病,应激性心肌病,短暂性左心室膨胀综合征,心尖球囊综合征，壶腹心肌病或心碎综合征；连同“医源性”，\"诱导\"或\"药物诱导\"。以英文或西班牙文出版的登记册，在人类中,并检索了全文。选择了认可与中药开发有关的任何药物的文章。
结果：总体而言，通过搜索确定了184份手稿。经过详尽的修订，共包括39篇文章。在当前更新中，确定了18种药物可能是TCM的触发因素。其中,3（16.7%）以前已经确定，15份(83.3%)与以往报告不同。因此，2022年更新的中医可能触发因素药物清单包括72种药物.
结论：有新的病例报告将药物与中药的发展联系起来。当前列表主要由产生交感神经过度刺激的药物组成。然而,一些列出的药物与交感神经激活没有明确的联系。
方法：类似于2011年和2016年的评论，从2015年4月至2022年5月,通过在Medline/PubMed数据库中进行全面搜索,确定了药物诱导的中医病例报告.搜索词是:塔科特subo心肌病，tako-tsubo心肌病,应激性心肌病,短暂性左心室膨胀综合征,心尖球囊综合征，壶腹心肌病或心碎综合征；连同“医源性”，\"诱导\"或\"药物诱导\"。以英文或西班牙文出版的登记册，在人类中,并检索了全文。选择了认可与中药开发有关的任何药物的文章。
结果：总体而言，通过搜索确定了184份手稿。经过详尽的修订，共包括39篇文章。在当前更新中，确定了18种药物可能是TCM的触发因素。其中,3（16.7%）以前已经确定，15份(83.3%)与以往报告不同。因此，2022年更新的中医可能触发因素药物清单包括72种药物.
结论：有新的病例报告将药物与中药的发展联系起来。当前列表主要由产生交感神经过度刺激的药物组成。然而,一些列出的药物与交感神经激活没有明确的联系。
