Abstract：
OBJECTIVE: To evaluate risk factors for poor prognosis in vocal fold leukoplakia.
METHODS: Clinical data were collected for 344 patients with vocal fold leukoplakia who received surgical treatment in our otolaryngology department from October 2010 to June 2019. Univariate and multivariate logistic regression analyses of the relevant factors were conducted.
RESULTS: Among the 344 patients, 98 exhibited recurrence and 30 underwent a malignant change. Multivariate logistic regression analysis showed that size of the lesion (p = 0.03, odds ratio = 2.14), form of the lesion under white light (p < 0.001), surgical method (p < 0.001, odds ratio = 0.28) and pathological type (p < 0.001) were independent factors that affected the recurrence of vocal fold leukoplakia. In both univariate and multivariate analyses, the sole independent risk factor for malignant transformation of vocal fold leukoplakia was pathological type (p < 0.001).
CONCLUSIONS: The outlook for vocal fold leukoplakia depends on several clinical factors, especially pathological type. The more severe the pathological type, the more likely it is to recur or become cancerous.
METHODS: Clinical data were collected for 344 patients with vocal fold leukoplakia who received surgical treatment in our otolaryngology department from October 2010 to June 2019. Univariate and multivariate logistic regression analyses of the relevant factors were conducted.
RESULTS: Among the 344 patients, 98 exhibited recurrence and 30 underwent a malignant change. Multivariate logistic regression analysis showed that size of the lesion (p = 0.03, odds ratio = 2.14), form of the lesion under white light (p < 0.001), surgical method (p < 0.001, odds ratio = 0.28) and pathological type (p < 0.001) were independent factors that affected the recurrence of vocal fold leukoplakia. In both univariate and multivariate analyses, the sole independent risk factor for malignant transformation of vocal fold leukoplakia was pathological type (p < 0.001).
CONCLUSIONS: The outlook for vocal fold leukoplakia depends on several clinical factors, especially pathological type. The more severe the pathological type, the more likely it is to recur or become cancerous.
摘要：
目的：评价声带白斑预后不良的危险因素。
方法：收集了2010年10月至2019年6月在耳鼻喉科接受手术治疗的344例声带白斑患者的临床资料。对相关因素进行单因素和多因素logistic回归分析。
结果：在344名患者中，98例复发，30例恶性改变。多因素logistic回归分析显示病灶大小(p=0.03,比值比=2.14),白光下病变的形式（p<0.001），手术方式（p<0.001，比值比=0.28）和病理类型（p<0.001）是影响声带白斑复发的独立因素。在单变量和多变量分析中，声带白斑恶变的唯一独立危险因素是病理类型（p<0.001）。
结论：声带白斑的前景取决于几个临床因素，尤其是病理类型。病理类型越严重,它越有可能复发或癌变。
方法：收集了2010年10月至2019年6月在耳鼻喉科接受手术治疗的344例声带白斑患者的临床资料。对相关因素进行单因素和多因素logistic回归分析。
结果：在344名患者中，98例复发，30例恶性改变。多因素logistic回归分析显示病灶大小(p=0.03,比值比=2.14),白光下病变的形式（p<0.001），手术方式（p<0.001，比值比=0.28）和病理类型（p<0.001）是影响声带白斑复发的独立因素。在单变量和多变量分析中，声带白斑恶变的唯一独立危险因素是病理类型（p<0.001）。
结论：声带白斑的前景取决于几个临床因素，尤其是病理类型。病理类型越严重,它越有可能复发或癌变。
