UNASSIGNED: We studied adults aged 41 to 52 years born with either LBW (≤2300 g) or normal birth weight (NBW; 3500-4000 g). GFR was measured using plasma clearance of iohexol. A stimulated GFR (sGFR) was measured on a separate day after a protein load of 100 g using a commercially available protein powder, and RFR was calculated as delta GFR. Kidney volume was estimated from magnetic resonance imaging (MRI) images using the ellipsoid formula.
UNASSIGNED: A total of 57 women and 48 men participated. The baseline mean ± SD GFR was 118 ± 17 ml/min for men and 98 ± 19 ml/min for women. The overall mean RFR was 8.2 ± 7.4 ml/min, with mean RFR of 8.3 ± 8.0 ml/min and 8.1 ± 6.9 ml/min in men and women, respectively (P = 0.5). No birth-related variables were associated with RFR. Larger kidney volume was associated with higher RFR, 1.9 ml/min per SD higher kidney volume (P = 0.009). Higher GFR per kidney volume was associated with a lower RFR, -3.3ml/min per SD (P < 0.001).
UNASSIGNED: Larger kidney size and lower GFR per kidney volume were associated with higher RFR. Birth weight was not shown to associate with RFR in mainly healthy middle-aged men and women.
■我们研究了41至52岁出生时体重低(≤2300g)或正常出生体重(NBW;3500-4000g)的成年人。使用碘海醇的血浆清除率测量GFR。刺激的GFR(sGFR)在单独的一天后,使用市售蛋白粉100g的蛋白质负荷后测量。和RFR计算为ΔGFR。使用椭球公式从磁共振成像(MRI)图像估计肾脏体积。
■共有57名女性和48名男性参加。男性的基线平均值±SDGFR为118±17ml/min,女性为98±19ml/min。总平均RFR为8.2±7.4ml/min,男性和女性的平均RFR为8.3±8.0ml/min和8.1±6.9ml/min,分别(P=0.5)。没有出生相关变量与RFR相关。较大的肾脏体积与较高的RFR相关,1.9ml/min每SD肾脏体积较高(P=0.009)。较高的每肾脏体积GFR与较低的RFR相关,每SD-3.3ml/min(P<0.001)。
■较大的肾脏大小和较低的每肾脏体积GFR与较高的RFR相关。在主要健康的中年男性和女性中,出生体重未显示与RFR相关。