PDF(Pubmed)
Abstract：
UNASSIGNED: Renal functional response (RFR) is the acute increase in glomerular filtration rate (GFR) after a protein load. Low RFR is a marker of single nephron hyperfiltration. Low birth weight (LBW) is associated with reduced number of nephrons, lower kidney function, and smaller kidneys in adults. In the present study, we investigate the associations among LBW, kidney volume, and RFR.
UNASSIGNED: We studied adults aged 41 to 52 years born with either LBW (≤2300 g) or normal birth weight (NBW; 3500-4000 g). GFR was measured using plasma clearance of iohexol. A stimulated GFR (sGFR) was measured on a separate day after a protein load of 100 g using a commercially available protein powder, and RFR was calculated as delta GFR. Kidney volume was estimated from magnetic resonance imaging (MRI) images using the ellipsoid formula.
UNASSIGNED: A total of 57 women and 48 men participated. The baseline mean ± SD GFR was 118 ± 17 ml/min for men and 98 ± 19 ml/min for women. The overall mean RFR was 8.2 ± 7.4 ml/min, with mean RFR of 8.3 ± 8.0 ml/min and 8.1 ± 6.9 ml/min in men and women, respectively (P = 0.5). No birth-related variables were associated with RFR. Larger kidney volume was associated with higher RFR, 1.9 ml/min per SD higher kidney volume (P = 0.009). Higher GFR per kidney volume was associated with a lower RFR, -3.3ml/min per SD (P < 0.001).
UNASSIGNED: Larger kidney size and lower GFR per kidney volume were associated with higher RFR. Birth weight was not shown to associate with RFR in mainly healthy middle-aged men and women.
UNASSIGNED: We studied adults aged 41 to 52 years born with either LBW (≤2300 g) or normal birth weight (NBW; 3500-4000 g). GFR was measured using plasma clearance of iohexol. A stimulated GFR (sGFR) was measured on a separate day after a protein load of 100 g using a commercially available protein powder, and RFR was calculated as delta GFR. Kidney volume was estimated from magnetic resonance imaging (MRI) images using the ellipsoid formula.
UNASSIGNED: A total of 57 women and 48 men participated. The baseline mean ± SD GFR was 118 ± 17 ml/min for men and 98 ± 19 ml/min for women. The overall mean RFR was 8.2 ± 7.4 ml/min, with mean RFR of 8.3 ± 8.0 ml/min and 8.1 ± 6.9 ml/min in men and women, respectively (P = 0.5). No birth-related variables were associated with RFR. Larger kidney volume was associated with higher RFR, 1.9 ml/min per SD higher kidney volume (P = 0.009). Higher GFR per kidney volume was associated with a lower RFR, -3.3ml/min per SD (P < 0.001).
UNASSIGNED: Larger kidney size and lower GFR per kidney volume were associated with higher RFR. Birth weight was not shown to associate with RFR in mainly healthy middle-aged men and women.
摘要：
■肾功能反应（RFR）是蛋白质负荷后肾小球滤过率（GFR）的急性增加。低RFR是单肾单位超滤的标志。低出生体重（LBW）与肾单位数量减少有关，降低肾功能，成人肾脏较小。在本研究中,我们调查了LBW之间的关联，肾脏体积,和RFR。
■我们研究了41至52岁出生时体重低（≤2300g）或正常出生体重（NBW;3500-4000g）的成年人。使用碘海醇的血浆清除率测量GFR。刺激的GFR（sGFR）在单独的一天后，使用市售蛋白粉100g的蛋白质负荷后测量。和RFR计算为ΔGFR。使用椭球公式从磁共振成像（MRI）图像估计肾脏体积。
■共有57名女性和48名男性参加。男性的基线平均值±SDGFR为118±17ml/min，女性为98±19ml/min。总平均RFR为8.2±7.4ml/min，男性和女性的平均RFR为8.3±8.0ml/min和8.1±6.9ml/min，分别(P=0.5)。没有出生相关变量与RFR相关。较大的肾脏体积与较高的RFR相关，1.9ml/min每SD肾脏体积较高(P=0.009)。较高的每肾脏体积GFR与较低的RFR相关，每SD-3.3ml/min(P<0.001)。
■较大的肾脏大小和较低的每肾脏体积GFR与较高的RFR相关。在主要健康的中年男性和女性中，出生体重未显示与RFR相关。
■我们研究了41至52岁出生时体重低（≤2300g）或正常出生体重（NBW;3500-4000g）的成年人。使用碘海醇的血浆清除率测量GFR。刺激的GFR（sGFR）在单独的一天后，使用市售蛋白粉100g的蛋白质负荷后测量。和RFR计算为ΔGFR。使用椭球公式从磁共振成像（MRI）图像估计肾脏体积。
■共有57名女性和48名男性参加。男性的基线平均值±SDGFR为118±17ml/min，女性为98±19ml/min。总平均RFR为8.2±7.4ml/min，男性和女性的平均RFR为8.3±8.0ml/min和8.1±6.9ml/min，分别(P=0.5)。没有出生相关变量与RFR相关。较大的肾脏体积与较高的RFR相关，1.9ml/min每SD肾脏体积较高(P=0.009)。较高的每肾脏体积GFR与较低的RFR相关，每SD-3.3ml/min(P<0.001)。
■较大的肾脏大小和较低的每肾脏体积GFR与较高的RFR相关。在主要健康的中年男性和女性中，出生体重未显示与RFR相关。
