Abstract：
Monocyte to high-density lipoprotein cholesterol ratio (MHR) has recently been identified as a new marker of inflammation and oxidative stress. However, it is unknown whether maternal MHR is associated with fetal weight at birth. Therefore, our objective was to analyze the association between maternal MHR and the frequency of small/large for gestational age (SGA/LGA) newborns in this retrospective cohort study.
We retrospectively analyzed hospitalization records and laboratory data and obtained results from consecutive pregnant women in whom the blood lipid level had been investigated along with the blood cell count. Linear regression and logistic regression analyses were performed to estimate the associations of maternal MHR with birth weight and SGA/LGA.
Monocyte counts and MHR were positively associated with birth weight/LGA risk (monocyte [1-109/L increase] for birth weight: β: 170.24, 95% confidence interval [CI]: 41.72-298.76, LGA: odds ratio [OR]: 7.67; 95% CI: 2.56-22.98; MHR [1-109/mmol increase] for birth weight: β: 294.84, 95% CI: 170.23-419.44, LGA: OR: 7.97; 95% CI: 3.06-20.70), whereas high-density lipoprotein cholesterol (HDL-C) levels were negatively associated with birth weight/LGA risk [1 mmol/L increase for birth weight (β: -99.83, 95% CI: -130.47 to -69.19), for LGA: (OR: 0.57, 95% CI: 0.45-0.73). Obese pregnant women (body mass index [BMI] ≥30 kg/m2) with higher MHR (tertile 3: >0.33 109/mmol) significantly increased LGA risk by 6.39 fold (95% CI: 4.81, 8.49) compared to those with low MHR (tertile 1-2: ≤0.33 109/mmol) and normal weight (BMI <25 kg/m2).
Maternal MHR is associated with LGA risk, and this association might be further modified by BMI.
We retrospectively analyzed hospitalization records and laboratory data and obtained results from consecutive pregnant women in whom the blood lipid level had been investigated along with the blood cell count. Linear regression and logistic regression analyses were performed to estimate the associations of maternal MHR with birth weight and SGA/LGA.
Monocyte counts and MHR were positively associated with birth weight/LGA risk (monocyte [1-109/L increase] for birth weight: β: 170.24, 95% confidence interval [CI]: 41.72-298.76, LGA: odds ratio [OR]: 7.67; 95% CI: 2.56-22.98; MHR [1-109/mmol increase] for birth weight: β: 294.84, 95% CI: 170.23-419.44, LGA: OR: 7.97; 95% CI: 3.06-20.70), whereas high-density lipoprotein cholesterol (HDL-C) levels were negatively associated with birth weight/LGA risk [1 mmol/L increase for birth weight (β: -99.83, 95% CI: -130.47 to -69.19), for LGA: (OR: 0.57, 95% CI: 0.45-0.73). Obese pregnant women (body mass index [BMI] ≥30 kg/m2) with higher MHR (tertile 3: >0.33 109/mmol) significantly increased LGA risk by 6.39 fold (95% CI: 4.81, 8.49) compared to those with low MHR (tertile 1-2: ≤0.33 109/mmol) and normal weight (BMI <25 kg/m2).
Maternal MHR is associated with LGA risk, and this association might be further modified by BMI.
摘要：
目的：单核细胞与高密度脂蛋白胆固醇的比值（MHR）最近被确定为炎症和氧化应激的新标志物。然而,目前尚不清楚母体MHR是否与出生时胎儿体重相关.因此,我们的目的是在这项回顾性队列研究中,分析母体MHR与小于/大于胎龄儿(SGA/LGA)新生儿频率之间的相关性.
方法：我们回顾性分析了住院记录和实验室数据，并获得了连续孕妇的血脂水平和血细胞计数的结果。进行线性回归和逻辑回归分析以估计母亲MHR与出生体重和SGA/LGA的关联。
结果：单核细胞计数和MHR与出生体重/LGA风险呈正相关（对于出生体重：β：170.24，95％置信区间[CI]：41.72-298.76，LGA：比值比[OR]：7.67；95％CI：2.56-22.98；MHR[1-17109/L增加]对于出生：4.06体重：4.44，20.44％L而高密度脂蛋白胆固醇（HDL-C）水平与出生体重/LGA风险呈负相关[出生体重增加1mmol/L（β：-99.83，95％CI：-130.47至-69.19），对于LGA：（OR：0.57，95%CI：0.45-0.73）。MHR较高（三元组3：>0.33109/mmol）的肥胖孕妇（体重指数[BMI]≥30kg/m2）与那些MHR较低（三元组1-2：≤0.33109/mmol）和正常体重（BMI<25kg/m2）的肥胖孕妇相比，LGA风险显着增加6.39倍（95％CI：4.81，8.49）。
结论：产妇MHR与LGA风险相关，这种关联可能会被BMI进一步修改。
方法：我们回顾性分析了住院记录和实验室数据，并获得了连续孕妇的血脂水平和血细胞计数的结果。进行线性回归和逻辑回归分析以估计母亲MHR与出生体重和SGA/LGA的关联。
结果：单核细胞计数和MHR与出生体重/LGA风险呈正相关（对于出生体重：β：170.24，95％置信区间[CI]：41.72-298.76，LGA：比值比[OR]：7.67；95％CI：2.56-22.98；MHR[1-17109/L增加]对于出生：4.06体重：4.44，20.44％L而高密度脂蛋白胆固醇（HDL-C）水平与出生体重/LGA风险呈负相关[出生体重增加1mmol/L（β：-99.83，95％CI：-130.47至-69.19），对于LGA：（OR：0.57，95%CI：0.45-0.73）。MHR较高（三元组3：>0.33109/mmol）的肥胖孕妇（体重指数[BMI]≥30kg/m2）与那些MHR较低（三元组1-2：≤0.33109/mmol）和正常体重（BMI<25kg/m2）的肥胖孕妇相比，LGA风险显着增加6.39倍（95％CI：4.81，8.49）。
结论：产妇MHR与LGA风险相关，这种关联可能会被BMI进一步修改。
