PDF(Pubmed)
Abstract：
Colloidal gold particles have been extensively studied for their potential in hyperthermia treatment due to their ability to become excited in the presence of an external laser. However, their light-to-heat efficiency is affected by the physiologic environment. In this study, we aimed to evaluate the ability of gold sphere, rod, and star-shaped colloids to elevate the temperature of blood plasma and breast cancer-simulated fluid under laser stimulation. Additionally, the dependence of optical properties and colloid stability of gold nanostructures with physiological medium, particle shape, and coating was determined. The light-to-heat efficiency of the gold particle is shape-dependent. The light-to-heat conversion efficiency of a star-shaped colloid is 36% higher than that of sphere-shaped colloids. However, the raised temperature of the surrounding medium is the lowest in the star-shaped colloid. When gold nanostructures are exited with a laser stimulation in a physiological fluid, the ions/cations attach to the surface of the gold particles, resulting in colloidal instability, which limits electron oscillation and diminishes the energy generated by the plasmonic excitation. Fluorescein (Fl) and polyethylene glycol (PEG) attached to gold spheres enhances their colloidal stability and light-to-heat efficiency; post-treatment, they remand their optical properties.
摘要：
已经广泛研究了胶体金颗粒在高温治疗中的潜力，因为它们能够在外部激光的存在下被激发。然而,它们的光热效率受生理环境的影响。在这项研究中,我们的目标是评估黄金球的能力，杆，和星形胶体在激光刺激下升高血浆和乳腺癌模拟流体的温度。此外,金纳米结构的光学性质和胶体稳定性与生理介质的依赖性，粒子形状,并确定涂层。金颗粒的光-热效率取决于形状。星形胶体的光热转换效率比球形胶体高36％。然而,周围介质的升高温度在星形胶体中是最低的。当金纳米结构在生理液体中通过激光刺激退出时，离子/阳离子附着在金颗粒的表面，导致胶体不稳定，这限制了电子振荡并减少了等离子体激发产生的能量。荧光素（Fl）和聚乙二醇（PEG）附着在金球上，增强了它们的胶体稳定性和光热效率；后处理，他们还记得他们的光学特性。
