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Abstract：
Dirofilariasis is an emerging vector-borne tropical disease of public health importance that mainly affects humans and dogs. Dirofilaria immitis and D. repens are the two well-documented dirofilariasis-causing filarioid helminths of both medical and veterinary concerns in India and Sri Lanka. This systematic review and meta-analysis aimed to describe and summarize the current evidence of dirofilariasis prevalence and distribution in India and Sri Lanka. Interestingly, D. repens is reported to circulate in both dogs (prevalence of 35.8% (95% CI: 11.23-60.69)) and humans (97% of published case reports) in India and Sri Lanka, but D. immitis is reported to be present in the dog populations in India (prevalence of 9.7% (95% CI: 8.5-11.0%)), and so far, it has not been reported in Sri Lanka. This peculiar distribution of D. immitis and D. repens in the two neighbouring countries could be due to the interaction between the two parasite species, which could affect the pattern of infection of the two worm species in dogs and thus influence the geographical distribution of these two filarial worms. In medical and veterinary practice, histopathology was the most commonly used diagnostic technique (31.3%; 95% CI 2.5-60.2%). The low specificity of histopathology to speciate the various Dirofilaria spp. may lead to misdiagnosis. It was identified in this study that several regions of India and Sri Lanka have not yet been surveyed for dirofilariasis. This limits our understanding of the geographical distribution and interspecies interactions of the two parasites within these countries. Parasite distribution, disease prevalence, and interspecies interactions between the vectors and the host should be targeted for future research.
摘要：
丝虫病是一种新兴的媒介传播的热带病，具有公共卫生重要性，主要影响人类和狗。Dirofilariaimmitis和D.repens是印度和斯里兰卡医学和兽医关注的两种有据可查的dirofilaria引起的丝虫蠕虫。本系统综述和荟萃分析旨在描述和总结印度和斯里兰卡的丝虫病患病率和分布的当前证据。有趣的是,据报道，印度和斯里兰卡的犬只（患病率为35.8％（95％CI：11.23-60.69））和人类（已发表病例报告的97％）都有繁殖。但是据报道，印度的狗群中存在D.immitis（患病率为9.7％（95％CI：8.5-11.0％）），到目前为止，斯里兰卡没有报道。D.immitis和D.repens在两个邻国的这种特殊分布可能是由于两种寄生虫物种之间的相互作用，这可能会影响两种蠕虫在狗中的感染模式，从而影响这两种丝虫的地理分布。在医学和兽医实践中，组织病理学是最常用的诊断技术(31.3%;95%CI2.5-60.2%).组织病理学对各种Dirofilariaspp的特异性较低。可能导致误诊。在这项研究中发现，印度和斯里兰卡的几个地区尚未接受过丝虫病调查。这限制了我们对这些国家内两种寄生虫的地理分布和种间相互作用的理解。寄生虫分布,疾病患病率，载体和宿主之间的种间相互作用应作为未来研究的目标。
