PDF(Pubmed)
Abstract：
Periostin, a secreted adhesion molecule, is a matricellular protein secreted most in periodontal ligament and periosteum. Periostin is also needed for integrity and maturation of periodontal tissue. This meta-analysis was conducted to compare the gingival crevicular fluid (GCF) periostin levels in subjects having periodontal disease and healthy periodontium.
In this meta-analysis, three international database including PubMed, Scopus and Web of Science were searched and 207 studies retrieved. Also, the Google Scholar was searched to find more related studies (two studies were found). To assess the risk of bias of included studies, the Newcastle-Ottawa assessment scale adapted for case-control was used. Finally, required data was extracted and included into analysis. All statistical analysis were done using Stata software.
Eight studies were included in this meta-analysis. Results showed that GCF periostin level is significant lower in chronic periodontitis group compare to healthy people (the standardized mean difference (SMD) = -3.15, 95% CI = -4.45, -1.85, p < 0.001). The syntheses of studies shown a significant decrease in the periostin level of chronic periodontitis patients compared to the gingivitis patients (SMD = -1.50, 95%CI = -2.52, -0.49, P = 0.003), while the mean level of periostin between the gingivitis patients and healthy group has no significant difference (SMD = -0.88, 95%CI = -2.14, 0.38, P = 0.173).
The mean concentration of GCF periostin in people with chronic periodontitis significantly decreased compared to people with gingivitis and also compared to healthy people, while no significant difference was observed between the two groups with gingivitis and healthy people. Therefore, this marker may be used as a diagnostic criterion for the disease, which requires further studies.
In this meta-analysis, three international database including PubMed, Scopus and Web of Science were searched and 207 studies retrieved. Also, the Google Scholar was searched to find more related studies (two studies were found). To assess the risk of bias of included studies, the Newcastle-Ottawa assessment scale adapted for case-control was used. Finally, required data was extracted and included into analysis. All statistical analysis were done using Stata software.
Eight studies were included in this meta-analysis. Results showed that GCF periostin level is significant lower in chronic periodontitis group compare to healthy people (the standardized mean difference (SMD) = -3.15, 95% CI = -4.45, -1.85, p < 0.001). The syntheses of studies shown a significant decrease in the periostin level of chronic periodontitis patients compared to the gingivitis patients (SMD = -1.50, 95%CI = -2.52, -0.49, P = 0.003), while the mean level of periostin between the gingivitis patients and healthy group has no significant difference (SMD = -0.88, 95%CI = -2.14, 0.38, P = 0.173).
The mean concentration of GCF periostin in people with chronic periodontitis significantly decreased compared to people with gingivitis and also compared to healthy people, while no significant difference was observed between the two groups with gingivitis and healthy people. Therefore, this marker may be used as a diagnostic criterion for the disease, which requires further studies.
摘要：
背景：Periostin，分泌的粘附分子，是一种在牙周膜和骨膜中分泌最多的基质细胞蛋白。牙周组织的完整性和成熟也需要骨膜素。进行此荟萃分析以比较患有牙周病和健康牙周组织的受试者的龈沟液（GCF）骨膜素水平。
方法：在本荟萃分析中，三个国际数据库，包括PubMed，搜索了Scopus和WebofScience，并检索了207项研究。此外，搜索了谷歌学者，以找到更多相关研究(发现了两项研究)。为了评估纳入研究的偏倚风险，采用适用于病例对照的纽卡斯尔-渥太华评定量表.最后,提取所需数据并纳入分析.所有统计分析均使用Stata软件进行。
结果：本荟萃分析包括8项研究。结果表明，与健康人群相比，慢性牙周炎组的GCF骨膜素水平显着降低（标准化平均差（SMD）=-3.15，95％CI=-4.45，-1.85，p<0.001）。综合研究显示，与牙龈炎患者相比，慢性牙周炎患者的骨膜素水平显着降低（SMD=-1.50，95CI=-2.52，-0.49，P=0.003），牙龈炎患者与健康组骨膜素的平均水平差异无统计学意义（SMD=-0.88，95CI=-2.14，0.38，P=0.173）。
结论：与牙龈炎患者相比，慢性牙周炎患者中GCF骨膜素的平均浓度显着降低，与健康人相比，而两组牙龈炎患者与健康人之间无显著差异。因此,该标记可以用作疾病的诊断标准，这需要进一步的研究。
方法：在本荟萃分析中，三个国际数据库，包括PubMed，搜索了Scopus和WebofScience，并检索了207项研究。此外，搜索了谷歌学者，以找到更多相关研究(发现了两项研究)。为了评估纳入研究的偏倚风险，采用适用于病例对照的纽卡斯尔-渥太华评定量表.最后,提取所需数据并纳入分析.所有统计分析均使用Stata软件进行。
结果：本荟萃分析包括8项研究。结果表明，与健康人群相比，慢性牙周炎组的GCF骨膜素水平显着降低（标准化平均差（SMD）=-3.15，95％CI=-4.45，-1.85，p<0.001）。综合研究显示，与牙龈炎患者相比，慢性牙周炎患者的骨膜素水平显着降低（SMD=-1.50，95CI=-2.52，-0.49，P=0.003），牙龈炎患者与健康组骨膜素的平均水平差异无统计学意义（SMD=-0.88，95CI=-2.14，0.38，P=0.173）。
结论：与牙龈炎患者相比，慢性牙周炎患者中GCF骨膜素的平均浓度显着降低，与健康人相比，而两组牙龈炎患者与健康人之间无显著差异。因此,该标记可以用作疾病的诊断标准，这需要进一步的研究。
