Abstract:
The aldosterone-to-renin ratio (ARR) is the standard screening test for primary aldosteronism (PA). Because of the poor reproducibility of the ARR, repeat testing is recommended if the result is not compatible with the clinical condition. Various methods to measure renin are used in different hospitals in Taiwan, and the ARR cutoff values also differ among laboratories. The Task Force of Taiwan PA recommend using plasma renin activity (PRA) to calculate ARR instead of direct renin concentration (DRC) unless PRA is unavailable, because PRA is widely used in international guidelines and most studies.
摘要:
醛固酮与肾素比率(ARR)是原发性醛固酮增多症(PA)的标准筛查测试。由于ARR的重现性差,如果结果与临床情况不符,建议重复测试。台湾不同医院采用多种方法测定肾素,ARR截止值在实验室之间也不同。台湾PA工作组建议使用血浆肾素活性(PRA)来计算ARR,而不是直接肾素浓度(DRC),除非PRA不可用,因为PRA在国际指南和大多数研究中被广泛使用。