Abstract：
Nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune receptors that restrict plant invasion by pathogens. Most NLRs operate in intricate networks to detect pathogen effectors in a robust and efficient manner. NLRs are not static sensors; rather, they exhibit remarkable mobility and structural plasticity during the innate immune response. Inactive NLRs localize to diverse subcellular compartments where they are poised to sense pathogen effectors. During pathogen attack, some NLRs relocate toward the plant-pathogen interface, possibly to ensure their timely activation. Activated NLRs reorganize into wheel-shaped oligomers, some of which then form plasma membrane pores that promote calcium influx and programmed cell death. The emerging paradigm is that this variable and dynamic nature underpins effective NLR-mediated immunity.
摘要：
富含核苷酸结合亮氨酸的重复序列（NLR）蛋白是限制病原体入侵植物的细胞内免疫受体。大多数NLR在复杂的网络中运行，以稳健有效的方式检测病原体效应物。NLR不是静态传感器；相反，它们在先天免疫反应期间表现出显著的移动性和结构可塑性。非活性NLR定位于不同的亚细胞区室，在那里它们准备感测病原体效应子。在病原体攻击期间，一些NLR重新定位到植物-病原体界面，可能是为了确保他们的及时激活。激活的NLR重组为轮状低聚物，其中一些然后形成质膜孔，促进钙流入和程序性细胞死亡。新兴的范式是，这种变量和动态性质支持有效的NLR介导的免疫。
