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Abstract：
One of the main limitations of 99mtechnetium-dimercaptosuccinic acid (DMSA) scan is the long acquisition time.
To evaluate the feasibility of short DMSA scan acquisition times using a cadmium-zinc-telluride-based single-photon emission computed tomography (SPECT) system in children.
The data of 27 children (median age: 4 years; 16 girls) who underwent DMSA SPECT were retrospectively analyzed. Both planar and SPECT DMSA were performed. SPECT images were analyzed using coronal-simulated planar two-dimensional images. A reduction in SPECT acquisition time was simulated to provide 4 series (SPECT-15 min, SPECT-10 min, SPECT-5 min and SPECT-2.5 min). A direct comparison of the planar and SPECT series was performed, including semi-quantification reproducibility, image quality (mean quality score on a scale of 0 to 2) and inter- and intra-observer reproducibility of the scintigraphic patterns.
The overall image quality score (± standard deviation) was 1.3 (± 0.6) for the planar data set, 1.6 (± 0.5) for the SPECT-15 min data set, 1.4 (± 0.5) for the SPECT-10 min data set, 1.0 (± 0.5) for the SPECT-5 min data set and 0.6 (± 0.6) for the SPECT-2.5 min data set. Median Kappa coefficients for inter-observer agreement between planar and SPECT images were greater than 0.83 for all series and all readers except one reader for the SPECT-2.5 min series (median Kappa coefficient = 0.77).
Shortening SPECT acquisitions to 5 min is feasible with minimal impact on images in terms of quality and reproducibility.
To evaluate the feasibility of short DMSA scan acquisition times using a cadmium-zinc-telluride-based single-photon emission computed tomography (SPECT) system in children.
The data of 27 children (median age: 4 years; 16 girls) who underwent DMSA SPECT were retrospectively analyzed. Both planar and SPECT DMSA were performed. SPECT images were analyzed using coronal-simulated planar two-dimensional images. A reduction in SPECT acquisition time was simulated to provide 4 series (SPECT-15 min, SPECT-10 min, SPECT-5 min and SPECT-2.5 min). A direct comparison of the planar and SPECT series was performed, including semi-quantification reproducibility, image quality (mean quality score on a scale of 0 to 2) and inter- and intra-observer reproducibility of the scintigraphic patterns.
The overall image quality score (± standard deviation) was 1.3 (± 0.6) for the planar data set, 1.6 (± 0.5) for the SPECT-15 min data set, 1.4 (± 0.5) for the SPECT-10 min data set, 1.0 (± 0.5) for the SPECT-5 min data set and 0.6 (± 0.6) for the SPECT-2.5 min data set. Median Kappa coefficients for inter-observer agreement between planar and SPECT images were greater than 0.83 for all series and all readers except one reader for the SPECT-2.5 min series (median Kappa coefficient = 0.77).
Shortening SPECT acquisitions to 5 min is feasible with minimal impact on images in terms of quality and reproducibility.
摘要：
背景：99mtech-二巯基琥珀酸（DMSA）扫描的主要局限性之一是采集时间长。
目的：评估在儿童中使用基于镉-锌-碲化物的单光子发射计算机断层扫描（SPECT）系统进行短DMSA扫描采集时间的可行性。
方法：回顾性分析27名接受DMSASPECT检查的儿童（中位年龄：4岁；16名女孩）的资料。进行了平面和SPECTDMSA。使用冠状模拟平面二维图像分析SPECT图像。模拟SPECT采集时间的减少，以提供4个系列(SPECT-15分钟，SPECT-10分钟,SPECT-5分钟和SPECT-2.5分钟)。进行了平面和SPECT系列的直接比较，包括半定量再现性，图像质量（0至2的平均质量评分）以及闪烁模式的观察者之间和观察者之间的可重复性。
结果：平面数据集的总体图像质量评分（±标准偏差）为1.3（±0.6），对于SPECT-15分钟数据集，为1.6（±0.5），1.4（±0.5）对于SPECT-10min数据集，对于SPECT-5分钟数据集1.0(±0.5),对于SPECT-2.5分钟数据集0.6(±0.6)。对于所有系列和所有读者，除了SPECT-2.5min系列的一个读者外，平面和SPECT图像之间的观察者间一致性的中值Kappa系数均大于0.83（中值Kappa系数=0.77）。
结论：将SPECT采集时间缩短至5分钟是可行的，并且在质量和再现性方面对图像的影响最小。
目的：评估在儿童中使用基于镉-锌-碲化物的单光子发射计算机断层扫描（SPECT）系统进行短DMSA扫描采集时间的可行性。
方法：回顾性分析27名接受DMSASPECT检查的儿童（中位年龄：4岁；16名女孩）的资料。进行了平面和SPECTDMSA。使用冠状模拟平面二维图像分析SPECT图像。模拟SPECT采集时间的减少，以提供4个系列(SPECT-15分钟，SPECT-10分钟,SPECT-5分钟和SPECT-2.5分钟)。进行了平面和SPECT系列的直接比较，包括半定量再现性，图像质量（0至2的平均质量评分）以及闪烁模式的观察者之间和观察者之间的可重复性。
结果：平面数据集的总体图像质量评分（±标准偏差）为1.3（±0.6），对于SPECT-15分钟数据集，为1.6（±0.5），1.4（±0.5）对于SPECT-10min数据集，对于SPECT-5分钟数据集1.0(±0.5),对于SPECT-2.5分钟数据集0.6(±0.6)。对于所有系列和所有读者，除了SPECT-2.5min系列的一个读者外，平面和SPECT图像之间的观察者间一致性的中值Kappa系数均大于0.83（中值Kappa系数=0.77）。
结论：将SPECT采集时间缩短至5分钟是可行的，并且在质量和再现性方面对图像的影响最小。
