{Reference Type}: Journal Article
{Title}: Ultrafast cadmium-zinc-telluride-based renal single-photon emission computed tomography: clinical validation.
{Author}: Dietz M;Jacquet-Francillon N;Bani Sadr A;Collette B;Mure PY;Demède D;Pina-Jomir G;Moreau-Triby C;Grégoire B;Mouriquand P;Janier M;Flaus A;
{Journal}: Pediatr Radiol
{Volume}: 53
{Issue}: 9
{Year}: 2023 08 12
{Factor}: 3.005
{DOI}: 10.1007/s00247-023-05682-x
{Abstract}: One of the main limitations of 99mtechnetium-dimercaptosuccinic acid (DMSA) scan is the long acquisition time.<BR>To evaluate the feasibility of short DMSA scan acquisition times using a cadmium-zinc-telluride-based single-photon emission computed tomography (SPECT) system in children.<BR>The data of 27 children (median age: 4 years; 16 girls) who underwent DMSA SPECT were retrospectively analyzed. Both planar and SPECT DMSA were performed. SPECT images were analyzed using coronal-simulated planar two-dimensional images. A reduction in SPECT acquisition time was simulated to provide 4 series (SPECT-15 min, SPECT-10 min, SPECT-5 min and SPECT-2.5 min). A direct comparison of the planar and SPECT series was performed, including semi-quantification reproducibility, image quality (mean quality score on a scale of 0 to 2) and inter- and intra-observer reproducibility of the scintigraphic patterns.<BR>The overall image quality score (± standard deviation) was 1.3 (± 0.6) for the planar data set, 1.6 (± 0.5) for the SPECT-15 min data set, 1.4 (± 0.5) for the SPECT-10 min data set, 1.0 (± 0.5) for the SPECT-5 min data set and 0.6 (± 0.6) for the SPECT-2.5 min data set. Median Kappa coefficients for inter-observer agreement between planar and SPECT images were greater than 0.83 for all series and all readers except one reader for the SPECT-2.5 min series (median Kappa coefficient = 0.77).<BR>Shortening SPECT acquisitions to 5 min is feasible with minimal impact on images in terms of quality and reproducibility.