Persistent Diarrhea and Eosinophilic Esophagitis Resulting From Chronic Cannabidiol Usage for Refractory Epilepsy.

慢性使用大麻二酚治疗难治性癫痫导致的持续性腹泻和嗜酸性食管炎。

• 发表时间: 2022 Nov
• 来源期刊: JPGN Rep
• DOI: 10.1097/PG9.0000000000000253
• PMID: 37168471
• 文章类型: Case Reports
• 作者列表: Patel M,Middleton JP,Goodkin HP,Barnes B,McGowan E,Eid R

关键词: cannabidiol; cannabinoid receptor 1; cannabinoid receptor 2; chronic diarrhea; eosinophilic esophagitis; esophageal eosinophilia; platelet activating factor; tetrahydrocannabinol; transient receptor potential cation channel subfamily V member 1

Abstract

Cannabidiol is used in the care of treatment-resistant epilepsy. It has been associated with varying side effects, ranging from somnolence to diarrhea and weight loss. We present a patient on chronic cannabidiol therapy who had persistent diarrhea, abdominal pain, weight loss, and esophageal eosinophilia that improved with cannabidiol dose adjustment.

摘要

大麻二酚用于治疗难治性癫痫。它与不同的副作用有关，从嗜睡到腹泻和体重减轻。我们介绍了一名患有持续性腹泻的慢性大麻二酚治疗患者，腹痛,减肥,和食管嗜酸性粒细胞增多，随着大麻二酚剂量的调整而改善。