Abstract：
Uropathogenic Escherichia coli (UPEC) is the main pathogen of recurrent urinary tract infections (RUTIs). Urinary tract infection is a complicated interaction between UPEC and the host. During infection, UPEC can evade the host\'s immune response and retain in bladder epithelial cells, which requires adequate nutritional support. Iron is the first necessary trace element in life and a key nutritional factor, making it an important part of the competition between UPEC and the host. On the one hand, UPEC grabs iron to satisfy its reproduction, on the other hand, the host relies on iron to build nutritional immunity defenses against UPEC. Ferritinophagy is a selective autophagy of ferritin mediated by nuclear receptor coactivator 4, which is not only a way for the host to regulate iron metabolism to maintain iron homeostasis, but also a key point of competition between the host and UPEC. Although recent studies have confirmed the role of ferritinophagy in the progression of many diseases, the mechanism of potential interactions between ferritinophagy in UPEC and the host is poorly understood. In this paper, we reviewed the potential mechanisms of ferritinophagy-mediated iron competition in the UPEC-host interactions. This competitive relationship, like a tug-of-war, is a confrontation between the capability of UPEC to capture iron and the host\'s nutritional immunity defense, which could be the trigger for RUTIs. Therefore, understanding ferritinophagy-mediated iron competition may provide new strategies for exploring effective antibiotic alternative therapies to prevent and treat RUTIs.
摘要：
尿路致病性大肠杆菌(UPEC)是复发性尿路感染(RUTIs)的主要病原体。尿路感染是UPEC与宿主之间复杂的相互作用。在感染期间,UPEC可以逃避宿主的免疫反应并保留在膀胱上皮细胞中，这需要足够的营养支持。铁是生命中第一个必需的微量元素，也是关键的营养因子。使其成为UPEC与主机之间竞争的重要组成部分。一方面,UPEC抓住铁来满足它的繁殖，另一方面,宿主依靠铁来建立针对UPEC的营养免疫防御。铁蛋白自噬是由核受体共激活因子4介导的铁蛋白选择性自噬,它不仅是宿主调节铁代谢维持铁稳态的一种途径,也是主机和UPEC之间竞争的关键点。尽管最近的研究已经证实了铁素吞噬在许多疾病的进展中的作用，UPEC中自噬铁与宿主之间潜在相互作用的机制尚不清楚。在本文中,我们综述了在UPEC-宿主相互作用中,铁粉吞噬介导的铁竞争的潜在机制.这种竞争关系,就像一场拔河,是UPEC捕获铁的能力与宿主的营养免疫防御之间的对抗，这可能是RUTI的触发器。因此,了解铁细胞吞噬介导的铁竞争可能为探索预防和治疗RUTI的有效抗生素替代疗法提供新策略.
