Abstract：
To report long-term outcomes of modern radiotherapy for sinonasal cancers.
A retrospective analysis of patients with sinonasal tumors treated with intensity-modulated radiotherapy or proton therapy. Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS).
Three hundred and eleven patients were included, with median follow-up of 75 months. The most common histologies were squamous cell (42%), adenoid cystic (15%), and sinonasal undifferentiated carcinoma (15%). Induction chemotherapy was administered to 47% of patients; 68% had adjuvant radiotherapy. Ten-year local control, regional control, distant metastasis free survival, PFS, and overall survival rates were 73%, 88%, 47%, 32%, and 51%, respectively. Age, non-nasal cavity tumor site, T3-4 stage, neck dissection, and radiation dose were predictive of PFS, while age, non-nasal cavity tumor site, T3-4 stage, positive margins, neck dissection, and use of neoadjuvant chemotherapy were predictive of OS. There was a 13% rate of late grade ≥3 toxicities.
This cohort of patients with sinonasal cancer treated with modern radiotherapy demonstrates favorable disease control rate and acceptable toxicity profile.
A retrospective analysis of patients with sinonasal tumors treated with intensity-modulated radiotherapy or proton therapy. Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS).
Three hundred and eleven patients were included, with median follow-up of 75 months. The most common histologies were squamous cell (42%), adenoid cystic (15%), and sinonasal undifferentiated carcinoma (15%). Induction chemotherapy was administered to 47% of patients; 68% had adjuvant radiotherapy. Ten-year local control, regional control, distant metastasis free survival, PFS, and overall survival rates were 73%, 88%, 47%, 32%, and 51%, respectively. Age, non-nasal cavity tumor site, T3-4 stage, neck dissection, and radiation dose were predictive of PFS, while age, non-nasal cavity tumor site, T3-4 stage, positive margins, neck dissection, and use of neoadjuvant chemotherapy were predictive of OS. There was a 13% rate of late grade ≥3 toxicities.
This cohort of patients with sinonasal cancer treated with modern radiotherapy demonstrates favorable disease control rate and acceptable toxicity profile.
摘要：
目的：报告现代放射治疗鼻窦肿瘤的长期结果。
方法：对接受调强放疗或质子治疗的鼻窦肿瘤患者进行回顾性分析。多变量分析用于确定无进展生存期（PFS）和总生存期（OS）的预测变量。
结果：纳入了三百一十一名患者，中位随访时间为75个月。最常见的组织学是鳞状细胞（42%），腺样囊性（15%），和鼻窦未分化癌（15%）。47%的患者接受了诱导化疗；68%的患者接受了辅助放疗。十年的地方控制，区域控制,无远处转移生存率，PFS,总生存率为73%,88%,47%,32%,51%,分别。年龄,非鼻腔肿瘤部位，T3-4级,颈淋巴结清扫术,辐射剂量可以预测PFS，而年龄,非鼻腔肿瘤部位，T3-4级,正利润率，颈淋巴结清扫术,新辅助化疗是OS的预测因素。晚期≥3级毒性率为13%。
结论：这个接受现代放射治疗的鼻腔鼻窦癌患者队列显示出良好的疾病控制率和可接受的毒性。
方法：对接受调强放疗或质子治疗的鼻窦肿瘤患者进行回顾性分析。多变量分析用于确定无进展生存期（PFS）和总生存期（OS）的预测变量。
结果：纳入了三百一十一名患者，中位随访时间为75个月。最常见的组织学是鳞状细胞（42%），腺样囊性（15%），和鼻窦未分化癌（15%）。47%的患者接受了诱导化疗；68%的患者接受了辅助放疗。十年的地方控制，区域控制,无远处转移生存率，PFS,总生存率为73%,88%,47%,32%,51%,分别。年龄,非鼻腔肿瘤部位，T3-4级,颈淋巴结清扫术,辐射剂量可以预测PFS，而年龄,非鼻腔肿瘤部位，T3-4级,正利润率，颈淋巴结清扫术,新辅助化疗是OS的预测因素。晚期≥3级毒性率为13%。
结论：这个接受现代放射治疗的鼻腔鼻窦癌患者队列显示出良好的疾病控制率和可接受的毒性。
