Abstract：
OBJECTIVE: Dysphonia is very common worldwide and aerosol drug inhalation is an important treatment for patients with dysphonia. This study aimed to explore the effects of vocal fold (VF) lesions on the particle deposition pattern using computational modeling.
METHODS: A realistic mouth-throat (MT) model of a healthy adult was constructed based on computed tomography images. Small and large vocal fold lesions were incorporated in the original model. A steady inhalation flowrate of 15 and 30 liter per minute (LPM) was used as the velocity inlet and monodisperse particles with diameters of 5 to 10 µm were simulated.
RESULTS: Particles of larger size are more likely to be deposited in MT models, most of them distributed in oral cavity, oropharynx and supraglottis. The ideal sizes at 30 LPM ranged over 7-10 µm for healthy VFs and 6-8 µm for VF lesions. The best sizes at 15 LPM ranged over 6-8 µm for healthy VFs and 8-9 µm for VF lesions.
CONCLUSIONS: Based on this study, VF lesions influence the deposition pattern in the glottis obviously. The ideal sizes differ at the flow rates of 15 and 30 LPM.
METHODS: A realistic mouth-throat (MT) model of a healthy adult was constructed based on computed tomography images. Small and large vocal fold lesions were incorporated in the original model. A steady inhalation flowrate of 15 and 30 liter per minute (LPM) was used as the velocity inlet and monodisperse particles with diameters of 5 to 10 µm were simulated.
RESULTS: Particles of larger size are more likely to be deposited in MT models, most of them distributed in oral cavity, oropharynx and supraglottis. The ideal sizes at 30 LPM ranged over 7-10 µm for healthy VFs and 6-8 µm for VF lesions. The best sizes at 15 LPM ranged over 6-8 µm for healthy VFs and 8-9 µm for VF lesions.
CONCLUSIONS: Based on this study, VF lesions influence the deposition pattern in the glottis obviously. The ideal sizes differ at the flow rates of 15 and 30 LPM.
摘要：
目的：发声障碍在世界范围内非常普遍，雾化吸入药物是发声障碍患者的重要治疗方法。本研究旨在使用计算模型探索声带（VF）病变对颗粒沉积模式的影响。
方法：基于计算机断层扫描图像构建了一个健康成年人的真实口喉（MT）模型。在原始模型中合并了小的和大的声带病变。使用每分钟15和30升（LPM）的稳定吸入流量作为速度入口，并模拟了直径为5至10µm的单分散颗粒。
结果：较大尺寸的颗粒更有可能沉积在MT模型中，大部分分布在口腔,口咽和声门上炎。对于健康的VF，30LPM时的理想尺寸超过7-10µm，对于VF病变为6-8µm。对于健康的VF，15LPM时的最佳尺寸范围为6-8µm，对于VF病变为8-9µm。
结论：基于这项研究，VF病变明显影响声门的沉积方式。理想尺寸在15和30LPM的流速下不同。
方法：基于计算机断层扫描图像构建了一个健康成年人的真实口喉（MT）模型。在原始模型中合并了小的和大的声带病变。使用每分钟15和30升（LPM）的稳定吸入流量作为速度入口，并模拟了直径为5至10µm的单分散颗粒。
结果：较大尺寸的颗粒更有可能沉积在MT模型中，大部分分布在口腔,口咽和声门上炎。对于健康的VF，30LPM时的理想尺寸超过7-10µm，对于VF病变为6-8µm。对于健康的VF，15LPM时的最佳尺寸范围为6-8µm，对于VF病变为8-9µm。
结论：基于这项研究，VF病变明显影响声门的沉积方式。理想尺寸在15和30LPM的流速下不同。
